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http://hdl.handle.net/10397/91368
| Title: | Property-tuneable microgels fabricated by using flow-focusing microfluidic geometry for bioactive agent delivery | Authors: | Lai, WF Wong, WT |
Issue Date: | Jun-2021 | Source: | Pharmaceutics, June 2021, v. 13, no. 6, 787 | Abstract: | Gelatine methacryloyl (GM) shows high biocompatibility and is extensively used in tissue engineering; however, few works have explored the use of GM in bioactive agent delivery. This study adopts a microfluidic approach involving the use of flow-focusing microfluidic geometry for microgel fabrication. This approach generates highly monodisperse microgels whose size can be tuned by altering various fabrication conditions (including the concentration of the gel-forming solution and the flow rates of different phases). By using tetracycline hydrochloride as a model agent, the fabricated microgels enable prolonged agent release, with the encapsulation efficiency being around 30–40% depending on the concentration of the gel-forming solution. Along with their negligible cytotoxicity, our microgels show the potential to serve as carriers of bioactive agents for food and pharmaceutical applications. | Keywords: | Controlled release Flow-focusing geometry Microfluidics Microgels Nutraceuticals |
Publisher: | Molecular Diversity Preservation International (MDPI) | Journal: | Pharmaceutics | EISSN: | 1999-4923 | DOI: | 10.3390/pharmaceutics13060787 | Rights: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). The following publication Lai,W.-F.;Wong,W.-T. Property-Tuneable Microgels Fabricated by Using Flow-Focusing Microfluidic Geometry for Bioactive Agent Delivery. Pharmaceutics 2021, 13, 787 is available at https://doi.org/10.3390/pharmaceutics13060787 |
| Appears in Collections: | Journal/Magazine Article |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| pharmaceutics-13-00787.pdf | 2.31 MB | Adobe PDF | View/Open | |
| Li_Understanding_Interaction_Technology.pdf | Pre-Published version | 718.9 kB | Adobe PDF | View/Open |
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