Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/91368
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorLai, WF-
dc.creatorWong, WT-
dc.date.accessioned2021-11-03T06:53:04Z-
dc.date.available2021-11-03T06:53:04Z-
dc.identifier.urihttp://hdl.handle.net/10397/91368-
dc.language.isoenen_US
dc.publisherMolecular Diversity Preservation International (MDPI)en_US
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en_US
dc.rightsThe following publication Lai,W.-F.;Wong,W.-T. Property-Tuneable Microgels Fabricated by Using Flow-Focusing Microfluidic Geometry for Bioactive Agent Delivery. Pharmaceutics 2021, 13, 787 is available at https://doi.org/10.3390/pharmaceutics13060787en_US
dc.subjectControlled releaseen_US
dc.subjectFlow-focusing geometryen_US
dc.subjectMicrofluidicsen_US
dc.subjectMicrogelsen_US
dc.subjectNutraceuticalsen_US
dc.titleProperty-tuneable microgels fabricated by using flow-focusing microfluidic geometry for bioactive agent deliveryen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume13-
dc.identifier.issue6-
dc.identifier.doi10.3390/pharmaceutics13060787-
dcterms.abstractGelatine methacryloyl (GM) shows high biocompatibility and is extensively used in tissue engineering; however, few works have explored the use of GM in bioactive agent delivery. This study adopts a microfluidic approach involving the use of flow-focusing microfluidic geometry for microgel fabrication. This approach generates highly monodisperse microgels whose size can be tuned by altering various fabrication conditions (including the concentration of the gel-forming solution and the flow rates of different phases). By using tetracycline hydrochloride as a model agent, the fabricated microgels enable prolonged agent release, with the encapsulation efficiency being around 30–40% depending on the concentration of the gel-forming solution. Along with their negligible cytotoxicity, our microgels show the potential to serve as carriers of bioactive agents for food and pharmaceutical applications.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationPharmaceutics, June 2021, v. 13, no. 6, 787-
dcterms.isPartOfPharmaceutics-
dcterms.issued2021-06-
dc.identifier.scopus2-s2.0-85107822394-
dc.identifier.eissn1999-4923-
dc.identifier.artn787-
dc.description.validate202110 bcvc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.pubStatusPublisheden_US
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