Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/91368
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Title: Property-tuneable microgels fabricated by using flow-focusing microfluidic geometry for bioactive agent delivery
Authors: Lai, WF 
Wong, WT 
Issue Date: Jun-2021
Source: Pharmaceutics, June 2021, v. 13, no. 6, 787
Abstract: Gelatine methacryloyl (GM) shows high biocompatibility and is extensively used in tissue engineering; however, few works have explored the use of GM in bioactive agent delivery. This study adopts a microfluidic approach involving the use of flow-focusing microfluidic geometry for microgel fabrication. This approach generates highly monodisperse microgels whose size can be tuned by altering various fabrication conditions (including the concentration of the gel-forming solution and the flow rates of different phases). By using tetracycline hydrochloride as a model agent, the fabricated microgels enable prolonged agent release, with the encapsulation efficiency being around 30–40% depending on the concentration of the gel-forming solution. Along with their negligible cytotoxicity, our microgels show the potential to serve as carriers of bioactive agents for food and pharmaceutical applications.
Keywords: Controlled release
Flow-focusing geometry
Microfluidics
Microgels
Nutraceuticals
Publisher: Molecular Diversity Preservation International (MDPI)
Journal: Pharmaceutics 
EISSN: 1999-4923
DOI: 10.3390/pharmaceutics13060787
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
The following publication Lai,W.-F.;Wong,W.-T. Property-Tuneable Microgels Fabricated by Using Flow-Focusing Microfluidic Geometry for Bioactive Agent Delivery. Pharmaceutics 2021, 13, 787 is available at https://doi.org/10.3390/pharmaceutics13060787
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