Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21977
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Title: Early local functional changes in the human diabetic retina : a global flash multifocal electroretinogram study
Authors: Lung, JCY
Swann, PG
Chan, HHL 
Issue Date: 2012
Source: Graefe's archive for clinical and experimental ophthalmology, Dec. 2012, v. 250, no. 12, p. 1745-1754
Abstract: Purpose: To investigate early functional changes of local retinal defects in type II diabetic patients using the global flash multifocal electroretinogram (MOFO mfERG). Methods: Thirty-eight diabetic patients and 14 age-matched controls were recruited. Nine of the diabetics were free from diabetic retinopathy (DR), while the remainder had mild to moderate non-proliferative diabetic retinopathy. The MOFO mfERG was performed at high (98%) and low (46%) contrast levels. MfERG responses were grouped into 35 regions for comparison with DR classification at those locations. Z-scores of the regional mfERG responses were compared across different types of DR defects. Results: The mfERG waveform consisted of the direct component (DC) and the induced component (IC). Local reduction in DC and IC amplitudes were found in diabetic patients with and without DR. With increasing severity of retinopathy, there was a further deterioration in amplitude of both components. Under MOFO mfERG paradigm, amplitude was a useful screening parameter. Conclusion: The MOFO mfERG can help in detecting early functional anomalies before the appearance of visible signs, and may assist in monitoring further functional deterioration in diabetic patients.
Keywords: Diabetes mellitus
Diabetic retinopathy
Electroretinogram
Global flash multifocal electroretinogram
Retinal adaptation
Retinal functions
Publisher: Springer
Journal: Graefe's archive for clinical and experimental ophthalmology 
ISSN: 0721-832X
EISSN: 1435-702X
DOI: 10.1007/s00417-012-2010-z
Rights: © Springer-Verlag 2012
This is a post-peer-review, pre-copyedit version of an article published in Graefe's Archive for Clinical and Experimental Ophthalmology. The final authenticated version is available online at: https://doi.org/10.1007/s00417-012-2010-z.
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