Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21977
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dc.contributorSchool of Optometryen_US
dc.creatorLung, JCYen_US
dc.creatorSwann, PGen_US
dc.creatorChan, HHLen_US
dc.date.accessioned2015-07-14T01:28:51Z-
dc.date.available2015-07-14T01:28:51Z-
dc.identifier.issn0721-832Xen_US
dc.identifier.urihttp://hdl.handle.net/10397/21977-
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rights© Springer-Verlag 2012en_US
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in Graefe's Archive for Clinical and Experimental Ophthalmology. The final authenticated version is available online at: https://doi.org/10.1007/s00417-012-2010-z.en_US
dc.subjectDiabetes mellitusen_US
dc.subjectDiabetic retinopathyen_US
dc.subjectElectroretinogramen_US
dc.subjectGlobal flash multifocal electroretinogramen_US
dc.subjectRetinal adaptationen_US
dc.subjectRetinal functionsen_US
dc.titleEarly local functional changes in the human diabetic retina : a global flash multifocal electroretinogram studyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1745en_US
dc.identifier.epage1754en_US
dc.identifier.volume250en_US
dc.identifier.issue2020-12en_US
dc.identifier.doi10.1007/s00417-012-2010-zen_US
dcterms.abstractPurpose: To investigate early functional changes of local retinal defects in type II diabetic patients using the global flash multifocal electroretinogram (MOFO mfERG). Methods: Thirty-eight diabetic patients and 14 age-matched controls were recruited. Nine of the diabetics were free from diabetic retinopathy (DR), while the remainder had mild to moderate non-proliferative diabetic retinopathy. The MOFO mfERG was performed at high (98%) and low (46%) contrast levels. MfERG responses were grouped into 35 regions for comparison with DR classification at those locations. Z-scores of the regional mfERG responses were compared across different types of DR defects. Results: The mfERG waveform consisted of the direct component (DC) and the induced component (IC). Local reduction in DC and IC amplitudes were found in diabetic patients with and without DR. With increasing severity of retinopathy, there was a further deterioration in amplitude of both components. Under MOFO mfERG paradigm, amplitude was a useful screening parameter. Conclusion: The MOFO mfERG can help in detecting early functional anomalies before the appearance of visible signs, and may assist in monitoring further functional deterioration in diabetic patients.en_US
dcterms.accessRightsopen access-
dcterms.bibliographicCitationGraefe's archive for clinical and experimental ophthalmology, Dec. 2012, v. 250, no. 12, p. 1745-1754en_US
dcterms.isPartOfGraefe's archive for clinical and experimental ophthalmologyen_US
dcterms.issued2012-
dc.identifier.isiWOS:000311366200005-
dc.identifier.scopus2-s2.0-84871301909-
dc.identifier.pmid22527315-
dc.identifier.eissn1435-702Xen_US
dc.identifier.rosgroupidr64215-
dc.description.ros2012-2013 > Academic research: refereed > Publication in refereed journalen_US
dc.description.oaAccepted Manuscript-
dc.identifier.FolderNumbera0764-n11, a0780-n06-
dc.identifier.SubFormID1615, 1630-
dc.description.fundingSourceOthers-
dc.description.fundingTextGU585, GU858, J-BB7P, J-BB76-
dc.description.pubStatusPublished-
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