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http://hdl.handle.net/10397/93844
Title: | Shrinkage in serial intervals across transmission generations of COVID-19 | Authors: | Zhao, S Zhao, Y Tang, B Gao, D Guo, Z Chong, MKC Musa, SS Cai, Y Wang, W He, D Wang, MH |
Issue Date: | 21-Nov-2021 | Source: | Journal of theoretical biology, 21 Nov. 2021, v. 529, 110861 | Abstract: | One of the key epidemiological characteristics that shape the transmission of coronavirus disease 2019 (COVID-19) is the serial interval (SI). Although SI is commonly considered following a probability distribution at a population scale, recent studies reported a slight shrinkage (or contraction) of the mean of effective SI across transmission generations or over time. Here, we develop a likelihood-based statistical inference framework with truncation to explore the change in SI across transmission generations after adjusting the impacts of case isolation. The COVID-19 contact tracing surveillance data in Hong Kong are used for exemplification. We find that for COVID-19, the mean of individual SI is likely to shrink with a factor at 0.72 per generation (95%CI: 0.54, 0.96) as the transmission generation increases, where a threshold may exist as the lower boundary of this shrinking process. We speculate that one of the probable explanations for the shrinkage in SI might be an outcome due to the competition among multiple candidate infectors within the same case cluster. Thus, the nonpharmaceutical interventive strategies are crucially important to block the transmission chains, and mitigate the COVID-19 epidemic. | Keywords: | Contact tracing COVID-19 Serial interval Statistical modelling Transmission generation |
Publisher: | Academic Press | Journal: | Journal of theoretical biology | EISSN: | 0022-5193 | DOI: | 10.1016/j.jtbi.2021.110861 | Rights: | © 2021 Elsevier Ltd. All rights reserved. © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ The following publication Zhao, S., Zhao, Y., Tang, B., Gao, D., Guo, Z., Chong, M. K., ... & Wang, M. H. (2021). Shrinkage in serial intervals across transmission generations of COVID-19. Journal of Theoretical Biology, 529, 110861 is available at https://doi.org/10.1016/j.jtbi.2021.110861 |
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Musa_Shrinkage_Serial_Intervals.pdf | Pre-Published versions | 1.77 MB | Adobe PDF | View/Open |
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