Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76961
Title: Alternative mRNA splicing in the pathogenesis of obesity
Authors: Wong, CM 
Xu, L 
Yau ,MYC
Keywords: Alternative mRNA splicing
Fox-1 Homolog 2
Insulin receptor
Leptin receptor
Lipin-1
LMNA
NOVA splicing factors
Nuclear receptor corepressor
Obesity-related diseases
RNA binding protein
Splice variants
Splicing factors
Issue Date: 2018
Publisher: Molecular Diversity Preservation International (MDPI)
Source: International journal of molecular sciences, 2018, v. 19, no. 2, 632 How to cite?
Journal: International journal of molecular sciences 
Abstract: Alternative mRNA splicing is an important mechanism in expansion of proteome diversity by production of multiple protein isoforms. However, emerging evidence indicates that only a limited number of annotated protein isoforms by alternative splicing are detected, and the coding sequence of alternative splice variants usually is only slightly different from that of the canonical sequence. Nevertheless, mis-splicing is associated with a large array of human diseases. Previous reviews mainly focused on hereditary and somatic mutations in cis-acting RNA sequence elements and trans-acting splicing factors. The importance of environmental perturbations contributed to mis-splicing is not assessed. As significant changes in exon skipping and splicing factors expression levels are observed with diet-induced obesity, this review focuses on several well-known alternatively spliced metabolic factors and discusses recent advances in the regulation of the expressions of splice variants under the pathophysiological conditions of obesity. The potential of targeting the alternative mRNA mis-splicing for obesity-associated diseases therapies will also be discussed.
URI: http://hdl.handle.net/10397/76961
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms19020632
Rights: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
The following publication Wong, C. M., Xu, L., & Yau, M. Y. C. (2018). Alternative mRNA Splicing in the Pathogenesis of Obesity. International journal of molecular sciences, 19(2), 632 is available at http://dx.doi.org/10.3390/ijms19020632
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