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Title: | Alternative mRNA splicing in the pathogenesis of obesity | Authors: | Wong, CM Xu, L Yau, MYC |
Issue Date: | 2018 | Source: | International journal of molecular sciences, 2018, v. 19, no. 2, 632 | Abstract: | Alternative mRNA splicing is an important mechanism in expansion of proteome diversity by production of multiple protein isoforms. However, emerging evidence indicates that only a limited number of annotated protein isoforms by alternative splicing are detected, and the coding sequence of alternative splice variants usually is only slightly different from that of the canonical sequence. Nevertheless, mis-splicing is associated with a large array of human diseases. Previous reviews mainly focused on hereditary and somatic mutations in cis-acting RNA sequence elements and trans-acting splicing factors. The importance of environmental perturbations contributed to mis-splicing is not assessed. As significant changes in exon skipping and splicing factors expression levels are observed with diet-induced obesity, this review focuses on several well-known alternatively spliced metabolic factors and discusses recent advances in the regulation of the expressions of splice variants under the pathophysiological conditions of obesity. The potential of targeting the alternative mRNA mis-splicing for obesity-associated diseases therapies will also be discussed. | Keywords: | Alternative mRNA splicing Fox-1 Homolog 2 Insulin receptor Leptin receptor Lipin-1 LMNA NOVA splicing factors Nuclear receptor corepressor Obesity-related diseases RNA binding protein Splice variants Splicing factors |
Publisher: | Molecular Diversity Preservation International (MDPI) | Journal: | International journal of molecular sciences | ISSN: | 1661-6596 | EISSN: | 1422-0067 | DOI: | 10.3390/ijms19020632 | Rights: | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). The following publication Wong, C. M., Xu, L., & Yau, M. Y. C. (2018). Alternative mRNA Splicing in the Pathogenesis of Obesity. International journal of molecular sciences, 19(2), 632 is available at http://dx.doi.org/10.3390/ijms19020632 |
Appears in Collections: | Journal/Magazine Article |
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