Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/76961
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Wong, CM | - |
dc.creator | Xu, L | - |
dc.creator | Yau, MYC | - |
dc.date.accessioned | 2018-07-17T07:11:19Z | - |
dc.date.available | 2018-07-17T07:11:19Z | - |
dc.identifier.issn | 1661-6596 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/76961 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) | en_US |
dc.rights | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Wong, C. M., Xu, L., & Yau, M. Y. C. (2018). Alternative mRNA Splicing in the Pathogenesis of Obesity. International journal of molecular sciences, 19(2), 632 is available at http://dx.doi.org/10.3390/ijms19020632 | en_US |
dc.subject | Alternative mRNA splicing | en_US |
dc.subject | Fox-1 Homolog 2 | en_US |
dc.subject | Insulin receptor | en_US |
dc.subject | Leptin receptor | en_US |
dc.subject | Lipin-1 | en_US |
dc.subject | LMNA | en_US |
dc.subject | NOVA splicing factors | en_US |
dc.subject | Nuclear receptor corepressor | en_US |
dc.subject | Obesity-related diseases | en_US |
dc.subject | RNA binding protein | en_US |
dc.subject | Splice variants | en_US |
dc.subject | Splicing factors | en_US |
dc.title | Alternative mRNA splicing in the pathogenesis of obesity | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.doi | 10.3390/ijms19020632 | en_US |
dcterms.abstract | Alternative mRNA splicing is an important mechanism in expansion of proteome diversity by production of multiple protein isoforms. However, emerging evidence indicates that only a limited number of annotated protein isoforms by alternative splicing are detected, and the coding sequence of alternative splice variants usually is only slightly different from that of the canonical sequence. Nevertheless, mis-splicing is associated with a large array of human diseases. Previous reviews mainly focused on hereditary and somatic mutations in cis-acting RNA sequence elements and trans-acting splicing factors. The importance of environmental perturbations contributed to mis-splicing is not assessed. As significant changes in exon skipping and splicing factors expression levels are observed with diet-induced obesity, this review focuses on several well-known alternatively spliced metabolic factors and discusses recent advances in the regulation of the expressions of splice variants under the pathophysiological conditions of obesity. The potential of targeting the alternative mRNA mis-splicing for obesity-associated diseases therapies will also be discussed. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | International journal of molecular sciences, 2018, v. 19, no. 2, 632 | - |
dcterms.isPartOf | International journal of molecular sciences | - |
dcterms.issued | 2018 | - |
dc.identifier.scopus | 2-s2.0-85042672012 | - |
dc.identifier.ros | 2017001986 | - |
dc.source.type | re | en |
dc.identifier.eissn | 1422-0067 | en_US |
dc.identifier.artn | 632 | en_US |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.identifier.rosgroupid | 2017001932 | - |
dc.description.ros | 2017-2018 > Academic research: refereed > Publication in refereed journal | - |
dc.description.validate | 201807 bcwh | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a0218-n03 | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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ijms-19-00632.pdf | 1.83 MB | Adobe PDF | View/Open |
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