Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/96170
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | Chan, CM | en_US |
dc.creator | Xing, Q | en_US |
dc.creator | Chow, YC | en_US |
dc.creator | Hung, SF | en_US |
dc.creator | Yu, WY | en_US |
dc.date.accessioned | 2022-11-11T07:56:50Z | - |
dc.date.available | 2022-11-11T07:56:50Z | - |
dc.identifier.issn | 1523-7060 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/96170 | - |
dc.language.iso | en | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | © 2019 American Chemical Society | en_US |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.9b03020. | en_US |
dc.title | Photoredox decarboxylative C(sp³)-N coupling of α-diazoacetates with alkyl N-hydroxyphthalimide esters for diversified synthesis of functionalized N-alkyl hydrazones | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 8037 | en_US |
dc.identifier.epage | 8043 | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 19 | en_US |
dc.identifier.doi | 10.1021/acs.orglett.9b03020 | en_US |
dcterms.abstract | Herein we report a metal-free photocatalytic coupling reaction for the synthesis of structurally and functionally diverse N-alkyl hydrazones from α-diazoacetates and N-alkyl hydroxyphthalimide esters. By employing Rose Bengal as a photocatalyst with yellow LEDs irradiation, over 60 N-alkyl hydrazones were synthesized. Fluorescence quenching analysis and deuterium incorporation experiments reveal that Hantzsch ester serves as both an electron donor and proton source for the reaction. This strategy offers a simple retrosynthetic disconnection for conventionally inaccessible C(sp³)-rich N-alkyl hydrazones. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Organic letters, 4 Oct. 2019, v. 21, no. 19, p. 8037-8043 | en_US |
dcterms.isPartOf | Organic letters | en_US |
dcterms.issued | 2019-10-04 | - |
dc.identifier.scopus | 2-s2.0-85072921786 | - |
dc.identifier.pmid | 31524416 | - |
dc.identifier.eissn | 1523-7052 | en_US |
dc.description.validate | 202211 bckw | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | RGC-B3-0032, ABCT-0352 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | The State Key Laboratory for Chemical Biology and Drug Discovery | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 22434798 | - |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Photoredox_Decarboxylative_Csp3-N.pdf | Pre-Published version | 615.62 kB | Adobe PDF | View/Open |
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