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http://hdl.handle.net/10397/95716
Title: | The small open reading frame-encoded peptides : advances in methodologies and functional studies | Authors: | Chen, L Yang, Y Zhang, Y Li, K Cai, H Wang, H Zhao, Q |
Issue Date: | 20-Apr-2022 | Source: | Chembiochem, 20 Apr. 2022, v. 23, no. 8, e202100534 | Abstract: | Small open reading frames (sORFs) are an important class of genes with less than 100 codons. They were historically annotated as noncoding or even junk sequences. In recent years, accumulating evidence suggests that sORFs could encode a considerable number of polypeptides, many of which play important roles in both physiology and disease pathology. However, it has been technically challenging to directly detect sORF-encoded peptides (SEPs). Here, we discuss the latest advances in methodologies for identifying SEPs with mass spectrometry, as well as the progress on functional studies of SEPs. | Keywords: | Mass spectrometry Proteins Proteomics Small open reading frames SORF-encoded peptides |
Publisher: | Wiley-VCH | Journal: | Chembiochem | ISSN: | 1439-4227 | EISSN: | 1439-7633 | DOI: | 10.1002/cbic.202100534 | Rights: | © 2021 Wiley-VCH GmbH This is the peer reviewed version of the following article: Chen, L., Yang, Y., Zhang, Y., Li, K., Cai, H., Wang, H., & Zhao, Q. (2022). The Small Open Reading Frame-Encoded Peptides: Advances in Methodologies and Functional Studies. ChemBioChem, 23(8), e202100534, which has been published in final form at https://doi.org/10.1002/cbic.202100534. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
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