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http://hdl.handle.net/10397/95490
Title: | Design, synthesis and comparison of water-soluble phthalocyanine/porphyrin analogues and their inhibition effects on Aβ₄₂ fibrillization | Authors: | Xu, W Gao, C Sun, X Tai, WCS Lung, HL Law, GL |
Issue Date: | 21-Jul-2021 | Source: | Inorganic chemistry frontiers, 21 July 2021, v. 8, no. 14, p. 3501-3513 | Abstract: | The misfolding and fibrillization of β amyloid (Aβ) is a major pathological hallmark of Alzheimer's disease (AD) and creates an important niche for developing targeted probe and drug designs. Phthalocyanine and porphyrin analogues are known to interact with Aβ species and interrupt their aggregation, and in this study we show that by conjugating with small molecules that can function as Aβ aggregation blockers such as curcumin and bexarotene, drug candidates with improved potential can be developed. In this work, we investigated porphyrin zinc (ZnPorp) analogues and phthalocyanine zinc (ZnPc) conjugates and compared their inhibitory effects on the formation of Aβ₄₂ fibrils. We show that probe designs with a good hydrophilic-hydrophobic balance as observed with the ZnPc conjugate analogues are deemed as better inhibitors in modulating Aβ₄₂ aggregation. | Publisher: | Royal Society of Chemistry | Journal: | Inorganic chemistry frontiers | ISSN: | 2052-1545 | EISSN: | 2052-1553 | DOI: | 10.1039/d1qi00237f | Rights: | This journal is © the Partner Organisations 2021 The following publication Xu, W., Gao, C., Sun, X., Tai, W. C. S., Lung, H. L., & Law, G. L. (2021). Design, synthesis and comparison of water-soluble phthalocyanine/porphyrin analogues and their inhibition effects on Aβ 42 fibrillization. Inorganic Chemistry Frontiers, 8(14), 3501-3513 is available at https://doi.org/10.1039/d1qi00237f. |
Appears in Collections: | Journal/Magazine Article |
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