Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/95490
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | Xu, W | en_US |
dc.creator | Gao, C | en_US |
dc.creator | Sun, X | en_US |
dc.creator | Tai, WCS | en_US |
dc.creator | Lung, HL | en_US |
dc.creator | Law, GL | en_US |
dc.date.accessioned | 2022-09-19T02:22:14Z | - |
dc.date.available | 2022-09-19T02:22:14Z | - |
dc.identifier.issn | 2052-1545 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/95490 | - |
dc.language.iso | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.rights | This journal is © the Partner Organisations 2021 | en_US |
dc.rights | The following publication Xu, W., Gao, C., Sun, X., Tai, W. C. S., Lung, H. L., & Law, G. L. (2021). Design, synthesis and comparison of water-soluble phthalocyanine/porphyrin analogues and their inhibition effects on Aβ 42 fibrillization. Inorganic Chemistry Frontiers, 8(14), 3501-3513 is available at https://doi.org/10.1039/d1qi00237f. | en_US |
dc.title | Design, synthesis and comparison of water-soluble phthalocyanine/porphyrin analogues and their inhibition effects on Aβ₄₂ fibrillization | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.description.otherinformation | Title on author's file: Design, synthesis and comparison of water-soluble phthalocyanine/porphyrin analogues and their inhibition on Aβ42 fibrillization | en_US |
dc.identifier.spage | 3501 | en_US |
dc.identifier.epage | 3513 | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 14 | en_US |
dc.identifier.doi | 10.1039/d1qi00237f | en_US |
dcterms.abstract | The misfolding and fibrillization of β amyloid (Aβ) is a major pathological hallmark of Alzheimer's disease (AD) and creates an important niche for developing targeted probe and drug designs. Phthalocyanine and porphyrin analogues are known to interact with Aβ species and interrupt their aggregation, and in this study we show that by conjugating with small molecules that can function as Aβ aggregation blockers such as curcumin and bexarotene, drug candidates with improved potential can be developed. In this work, we investigated porphyrin zinc (ZnPorp) analogues and phthalocyanine zinc (ZnPc) conjugates and compared their inhibitory effects on the formation of Aβ₄₂ fibrils. We show that probe designs with a good hydrophilic-hydrophobic balance as observed with the ZnPc conjugate analogues are deemed as better inhibitors in modulating Aβ₄₂ aggregation. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Inorganic chemistry frontiers, 21 July 2021, v. 8, no. 14, p. 3501-3513 | en_US |
dcterms.isPartOf | Inorganic chemistry frontiers | en_US |
dcterms.issued | 2021-07-21 | - |
dc.identifier.scopus | 2-s2.0-85110495954 | - |
dc.identifier.eissn | 2052-1553 | en_US |
dc.description.validate | 202209_bcww | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | ABCT-0079 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | HKBU Inter-institutional Collaborative Research Scheme; seed money from the Faculty of Science of HKBU to new academic staff | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 55718626 | - |
dc.description.oaCategory | Green (AAM) | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Xu_Design_Synthesis_Comparison.pdf | Pre-Published version | 1.27 MB | Adobe PDF | View/Open |
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