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http://hdl.handle.net/10397/95460
Title: | One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy | Authors: | Chu, JCH Shao, C Ha, SYY Fong, WP Wong, CTT Ng, DKP |
Issue Date: | 7-Dec-2021 | Source: | Biomaterials science, 7 Dec. 2021, v. 9, no. 23, p. 7832-7837 | Abstract: | We report herein a one-pot approach to cyclise a tumour-Targeting peptide and conjugate it on the surface of red blood cells loaded with a boron dipyrromethene-based photosensitiser using a bifunctional linker consisting of a bis(bromomethyl)phenyl unit and an ortho-phthalaldehyde unit. This cell-based photosensitiser with surface modification with cyclic RGD peptide moieties can selectively bind against the αvβ3 integrin-overexpressed cancer cells, leading to enhanced photocytotoxicity. The results demonstrate that this facile strategy is effective for live-cell surface modification for a wide range of applications. | Publisher: | Royal Society of Chemistry | Journal: | Biomaterials science | ISSN: | 2047-4830 | EISSN: | 2047-4849 | DOI: | 10.1039/d1bm01306h | Rights: | This journal is © The Royal Society of Chemistry 2021 The following publication Chu, J. C., Shao, C., Ha, S. Y., Fong, W. P., Wong, C. T., & Ng, D. K. (2021). One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy. Biomaterials Science, 9(23), 7832-7837 is available at https://doi.org/10.1039/d1bm01306h. |
Appears in Collections: | Journal/Magazine Article |
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Shao_One-Pot_Peptide_Cyclisation.pdf | Pre-Published version | 985.88 kB | Adobe PDF | View/Open |
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