Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/94376
Title: | PM2.5 as a potential risk factor for autism spectrum disorder : its possible link to neuroinflammation, oxidative stress and changes in gene expression | Authors: | Ahadullah Yau, SY Lu, HX Lee, TMC Guo, H Chan, CCH |
Issue Date: | Sep-2021 | Source: | Neuroscience & biobehavioral reviews, Sept. 2021, v. 128, p. 534-548 | Abstract: | Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral deficits including impairments in social communication, social interaction, and repetitive behaviors. Because the etiology of ASD is still largely unknown, there is no cure for ASD thus far. Although it has been established that genetic components play a vital role in ASD development, the influence of epigenetic regulation induced by environmental factors could also contribute to ASD susceptibility. Accumulated evidence has suggested that exposure to atmospheric particulate matter (PM) in polluted air could affect neurodevelopment, thus possibly leading to ASD. Particles with a size of 2.5 μm (PM2.5) or less have been shown to have negative effects on human health, and could be linked to ASD symptoms in children. This review summarizes evidence from clinical and animal studies to demonstrate the possible linkage between PM2.5 exposure and the incidence of ASD in children. An attempt was made to explore the possible mechanisms of this linkage, including changes of gene expression, oxidative stress and neuroinflammation induced by PM2.5 exposure. | Keywords: | Autism spectrum disorder Neuroinflammation Oxidative stress Changes of gene expression PM2.5 |
Publisher: | Pergamon | Journal: | Neuroscience & biobehavioral reviews | ISSN: | 0149-7634 | DOI: | 10.1016/j.neubiorev.2021.06.043 | Rights: | © 2021 Published by Elsevier Ltd. © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The following publication Ahadullah, Yau, S.-y., Lu, H.-x., Lee, T. M. C., Guo, H., & Chan, C. C. H. (2021). PM2.5 as a potential risk factor for autism spectrum disorder: Its possible link to neuroinflammation, oxidative stress and changes in gene expression. Neuroscience & Biobehavioral Reviews, 128, 534-548 is available at https://dx.doi.org/10.1016/j.neubiorev.2021.06.043. |
Appears in Collections: | Journal/Magazine Article |
Show full item record
Page views
64
Last Week
0
0
Last month
Citations as of Oct 13, 2024
SCOPUSTM
Citations
16
Citations as of Oct 10, 2024
WEB OF SCIENCETM
Citations
16
Citations as of Oct 17, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.