Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/94376
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Rehabilitation Sciences | en_US |
dc.contributor | Department of Civil and Environmental Engineering | en_US |
dc.creator | Ahadullah | en_US |
dc.creator | Yau, SY | en_US |
dc.creator | Lu, HX | en_US |
dc.creator | Lee, TMC | en_US |
dc.creator | Guo, H | en_US |
dc.creator | Chan, CCH | en_US |
dc.date.accessioned | 2022-08-12T05:09:34Z | - |
dc.date.available | 2022-08-12T05:09:34Z | - |
dc.identifier.issn | 0149-7634 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/94376 | - |
dc.language.iso | en | en_US |
dc.publisher | Pergamon | en_US |
dc.rights | © 2021 Published by Elsevier Ltd. | en_US |
dc.rights | © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. | en_US |
dc.rights | The following publication Ahadullah, Yau, S.-y., Lu, H.-x., Lee, T. M. C., Guo, H., & Chan, C. C. H. (2021). PM2.5 as a potential risk factor for autism spectrum disorder: Its possible link to neuroinflammation, oxidative stress and changes in gene expression. Neuroscience & Biobehavioral Reviews, 128, 534-548 is available at https://dx.doi.org/10.1016/j.neubiorev.2021.06.043. | en_US |
dc.subject | Autism spectrum disorder | en_US |
dc.subject | Neuroinflammation | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Changes of gene expression | en_US |
dc.subject | PM2.5 | en_US |
dc.title | PM2.5 as a potential risk factor for autism spectrum disorder : its possible link to neuroinflammation, oxidative stress and changes in gene expression | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 534 | en_US |
dc.identifier.epage | 548 | en_US |
dc.identifier.volume | 128 | en_US |
dc.identifier.doi | 10.1016/j.neubiorev.2021.06.043 | en_US |
dcterms.abstract | Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral deficits including impairments in social communication, social interaction, and repetitive behaviors. Because the etiology of ASD is still largely unknown, there is no cure for ASD thus far. Although it has been established that genetic components play a vital role in ASD development, the influence of epigenetic regulation induced by environmental factors could also contribute to ASD susceptibility. Accumulated evidence has suggested that exposure to atmospheric particulate matter (PM) in polluted air could affect neurodevelopment, thus possibly leading to ASD. Particles with a size of 2.5 μm (PM2.5) or less have been shown to have negative effects on human health, and could be linked to ASD symptoms in children. This review summarizes evidence from clinical and animal studies to demonstrate the possible linkage between PM2.5 exposure and the incidence of ASD in children. An attempt was made to explore the possible mechanisms of this linkage, including changes of gene expression, oxidative stress and neuroinflammation induced by PM2.5 exposure. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Neuroscience & biobehavioral reviews, Sept. 2021, v. 128, p. 534-548 | en_US |
dcterms.isPartOf | Neuroscience & biobehavioral reviews | en_US |
dcterms.issued | 2021-09 | - |
dc.identifier.isi | WOS:000679529700005 | - |
dc.identifier.scopus | 2-s2.0-85109759009 | - |
dc.identifier.pmid | 34216652 | - |
dc.description.validate | 202208 bckw | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | a1497 | - |
dc.identifier.SubFormID | 45182 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Hong Kong Polytechnic University; Key-Area Research and Development Program of Guangdong Province | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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