Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/91966
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Rehabilitation Sciences | - |
dc.creator | Kranz, GS | - |
dc.creator | Spies, M | - |
dc.creator | Vraka, C | - |
dc.creator | Kaufmann, U | - |
dc.creator | Klebermass, EM | - |
dc.creator | Handschuh, PA | - |
dc.creator | Ozenil, M | - |
dc.creator | Murgaš, M | - |
dc.creator | Pichler, V | - |
dc.creator | Rischka, L | - |
dc.creator | Nics, L | - |
dc.creator | Konadu, ME | - |
dc.creator | Ibeschitz, H | - |
dc.creator | Traub-Weidinger, T | - |
dc.creator | Wadsak, W | - |
dc.creator | Hahn, A | - |
dc.creator | Hacker, M | - |
dc.creator | Lanzenberger, R | - |
dc.date.accessioned | 2022-02-07T07:04:38Z | - |
dc.date.available | 2022-02-07T07:04:38Z | - |
dc.identifier.issn | 0306-4530 | - |
dc.identifier.uri | http://hdl.handle.net/10397/91966 | - |
dc.language.iso | en | en_US |
dc.publisher | Pergamon | en_US |
dc.rights | © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Kranz, G. S., Spies, M., Vraka, C., Kaufmann, U., Klebermass, E. M., Handschuh, P. A., ... & Lanzenberger, R. (2021). High-dose testosterone treatment reduces monoamine oxidase A levels in the human brain: A preliminary report. Psychoneuroendocrinology, 133, 105381 is available at https://doi.org/10.1016/j.psyneuen.2021.105381 | en_US |
dc.subject | Estradiol | en_US |
dc.subject | Gender dysphoria | en_US |
dc.subject | Gender-affirming hormone treatment | en_US |
dc.subject | Monoamine oxidase A | en_US |
dc.subject | Positron emission tomography | en_US |
dc.subject | Testosterone | en_US |
dc.subject | Transgender | en_US |
dc.title | High-dose testosterone treatment reduces monoamine oxidase A levels in the human brain : a preliminary report | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 133 | - |
dc.identifier.doi | 10.1016/j.psyneuen.2021.105381 | - |
dcterms.abstract | The sex hormones testosterone and estradiol influence brain structure and function and are implicated in the pathogenesis, prevalence and disease course of major depression. Recent research employing gender-affirming hormone treatment (GHT) of gender dysphoric individuals and utilizing positron emission tomography (PET) indicates increased serotonin transporter binding upon high-dosages of testosterone treatment. Here, we investigated the effects of GHT on levels of monoamine oxidase A (MAO-A), another key target of antidepressant treatment. Participants underwent PET with the radioligand [11C]harmine to assess cerebral MAO-A distribution volumes (VT) before and four months after initiation of GHT. By the time this study was terminated for technical reasons, 18 transgender individuals undergoing GHT (11 transmen, TM and 7 transwomen, TW) and 17 cis-gender subjects had been assessed. Preliminary analysis of available data revealed statistically significant MAO-A VT reductions in TM under testosterone treatment in six of twelve a priori defined regions of interest (middle frontal cortex (−10%), anterior cingulate cortex (−9%), medial cingulate cortex (−10.5%), insula (−8%), amygdala (−9%) and hippocampus (−8.5%, all p<0.05)). MAO-A VT did not change in TW receiving estrogen treatment. Despite the limited sample size, pronounced MAO-A VT reduction could be observed, pointing towards a potential effect of testosterone. Considering MAO-A's central role in regulation of serotonergic neurotransmission, changes to MAO-A VT should be further investigated as a possible mechanism by which testosterone mediates risk for, symptomatology of, and treatment response in affective disorders. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Psychoneuroendocrinology, Nov. 2021, v. 133, 105381 | - |
dcterms.isPartOf | Psychoneuroendocrinology | - |
dcterms.issued | 2021-09 | - |
dc.identifier.scopus | 2-s2.0-85112491439 | - |
dc.identifier.eissn | 1873-3360 | - |
dc.identifier.artn | 105381 | - |
dc.description.validate | 202202 bcvc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | This study was supported by a grant from the Austrian Science Fund to R. Lanzenberger (FWF grant number K LI 50 4 ). M. Murgas is funded by the Austrian Science Fund (FWF), D OC 33-B2 7 . L. Rischka was a recipient of a DOC Fellowship of the Austrian Academy of Sciences at the Department of Psychiatry and Psychotherapy, Medical University of Vienna. | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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1-s2.0-S0306453021002559-main.pdf | 1.17 MB | Adobe PDF | View/Open |
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