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Title: Estimated prevalence and viral transmissibility in subjects with asymptomatic SARS-CoV-2 infections in Wuhan, China
Authors: Zhang, K
Tong, WW
Wang, XH
Lau, JYN 
Issue Date: Dec-2020
Source: Precision clinical medicine, Dec. 2020, v. 3, no. 4, p. 301-305
Abstract: The role of subjects with asymptomatic SARS-CoV-2 infection in the current pandemic is not well-defined. Based on two different approaches to estimate the culminative attack rate (seroprevalence of antibodies against SARS-CoV-2, and a four compartment mathematical model) and the reported number of patients with COVID-19, the ratio of asymptomatic versus symptomatic SARS-CoV-2 infection was estimated to be 7 (95% CI: 2.8-12.4) in Wuhan, Hubei, China, the first epicenter of this pandemic, which has settled with no new cases. Together with detailed recording of the contact sources in a cohort of patients, and applying the estimations to an established mathematical model, the viral transmissibility of the subjects with asymptomatic SARS-CoV-2 infection is around 10% of that of the symptomatic patients (95% CI: 7.6%-12.3%). Public health measures/policies should address this important pool of infectious source in combat against this viral pandemic.
Keywords: Asymptomatic carriers
Publisher: Oxford University Press
Journal: Precision clinical medicine 
ISSN: 2096-5303
EISSN: 2516-1571
DOI: 10.1093/pcmedi/pbaa032
Rights: © The Author(s) 2020. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
The following publication Zhang, K., Tong, W., Wang, X., & Lau, J. Y. N. (2020). Estimated prevalence and viral transmissibility in subjects with asymptomatic SARS-CoV-2 infections in Wuhan, China. Precision Clinical Medicine, 3(4), 301-305 is available at
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