Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/91677
Title: Estimated prevalence and viral transmissibility in subjects with asymptomatic SARS-CoV-2 infections in Wuhan, China
Authors: Zhang, K
Tong, WW
Wang, XH
Lau, JYN 
Issue Date: Dec-2020
Source: Precision clinical medicine, Dec. 2020, v. 3, no. 4, p. 301-305
Abstract: The role of subjects with asymptomatic SARS-CoV-2 infection in the current pandemic is not well-defined. Based on two different approaches to estimate the culminative attack rate (seroprevalence of antibodies against SARS-CoV-2, and a four compartment mathematical model) and the reported number of patients with COVID-19, the ratio of asymptomatic versus symptomatic SARS-CoV-2 infection was estimated to be 7 (95% CI: 2.8-12.4) in Wuhan, Hubei, China, the first epicenter of this pandemic, which has settled with no new cases. Together with detailed recording of the contact sources in a cohort of patients, and applying the estimations to an established mathematical model, the viral transmissibility of the subjects with asymptomatic SARS-CoV-2 infection is around 10% of that of the symptomatic patients (95% CI: 7.6%-12.3%). Public health measures/policies should address this important pool of infectious source in combat against this viral pandemic.
Keywords: Asymptomatic carriers
Infection
COVID-19
Publisher: Oxford University Press
Journal: Precision clinical medicine 
ISSN: 2096-5303
EISSN: 2516-1571
DOI: 10.1093/pcmedi/pbaa032
Rights: © The Author(s) 2020. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
The following publication Kang Zhang, Weiwei Tong, Xinghuan Wang, Johnson Yiu-Nam Lau, Estimated prevalence and viral transmissibility in subjects with asymptomatic SARS-CoV-2 infections in Wuhan, China, Precision Clinical Medicine, Volume 3, Issue 4, December 2020, Pages 301–305 is available at https://doi.org/10.1093/pcmedi/pbaa032
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.