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Title: Semi-individualized acupuncture for insomnia disorder and oxidative stress : a randomized, double-blind, sham-controlled trial
Authors: Yeung, WF 
Yuen, JWM 
Ho, JYS 
Chung, KF
Zhang, ZJ
Mak, DSY
Suen, LKP
Ho, LM
Issue Date: 2021
Source: Nature and science of sleep, 2021, v. 13, p. 1195-1207
Abstract: Background: Acupuncture is an alternative treatment for improving sleep, and it may attenuate oxidative stress, which is a possible pathophysiological factor in insomnia. The aim of this study was to examine the efficacy and safety of a semi-individualized acupuncture in improving sleep and explore its effect on oxidative stress parameters in adults with insomnia disorder.
Methods: In this randomized sham-controlled trial, 140 participants were randomly assigned to either a 4-week semi-individualized traditional acupuncture (TA) or noninvasive sham acupuncture (SA). The primary outcome measure was the sleep-diary-derived sleep efficiency. Other outcomes included sleep diary and actigraphy, Insomnia Severity Index, anxiety and depressive symptoms, and quality of life. Blood samples were taken to measure oxidative stress parameters (malondialdehyde, glutathione peroxidase, paraoxonase, and arylesterase).
Results: Although no significant difference was found in the primary outcome measure, both sleep-diary-derived and actigraphy-derived total sleep time (TST) were significantly increased in the TA group at 1-week posttreatment (mean difference in sleep diary = 22.0 min, p = 0.01, actigraphy = 18.8 min, p = 0.02). At 5-week posttreatment follow-up, a significantly higher proportion of participants in the TA group showed sleep-diary-derived sleep efficiency (SE) >= 85% than in the SA group (55.6% versus 36.4%, p = 0.03).
Conclusion: TA and SA did not significantly differ in improving subjective sleep efficiency in individuals with insomnia disorder. However, the TA group showed a short-term effect on improving TST as measured by both sleep diary and actigraphy at 1-week posttreatment, but there were no differences in the oxidative stress parameters.
Keywords: Sleep
Oxidative stress
Chinese medicine
Publisher: Dove Medical Press
Journal: Nature and science of sleep 
EISSN: 1179-1608
DOI: 10.2147/NSS.S318874
Rights: © 2021 Yeung et al. This work is published and licensed by Dove Medical Press Limited.
The full terms of this license are available at and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (
The following publication Yeung, W. F., Yu, B. Y. M., Yuen, J. W. M., Ho, J. Y. S., Chung, K. F., Zhang, Z. J., ... & Ho, L. M. (2021). Semi-individualized acupuncture for insomnia disorder and oxidative stress: a randomized, double-Blind, sham-controlled trial. Nature and Science of Sleep, 13, 1195-1207 is available at
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