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http://hdl.handle.net/10397/89328
| Title: | In search of molecular markers for cerebellar neurons | Authors: | Tam, WY Wang, X Cheng, ASK Cheung, KK |
Issue Date: | Feb-2021 | Source: | International journal of molecular sciences, Feb. 2021, v. 22, no. 4, 1850, p. 1-11 | Abstract: | The cerebellum, the region of the brain primarily responsible for motor coordination and balance, also contributes to non-motor functions, such as cognition, speech, and language compre-hension. Maldevelopment and dysfunction of the cerebellum lead to cerebellar ataxia and may even be associated with autism, depression, and cognitive deficits. Hence, normal development of the cerebellum and its neuronal circuitry is critical for the cerebellum to function properly. Although nine major types of cerebellar neurons have been identified in the cerebellar cortex to date, the exact functions of each type are not fully understood due to a lack of cell-specific markers in neurons that renders cell-specific labeling and functional study by genetic manipulation unfeasible. The availa-bility of cell-specific markers is thus vital for understanding the role of each neuronal type in the cerebellum and for elucidating the interactions between cell types within both the developing and mature cerebellum. This review discusses various technical approaches and recent progress in the search for cell-specific markers for cerebellar neurons. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | Keywords: | Cerebellum Genetics Laser-capture microdissection Neuronal marker Next-generation sequencing Single-cell transcriptome |
Publisher: | Molecular Diversity Preservation International (MDPI)2 February 2021, | Journal: | International journal of molecular sciences | ISSN: | 1661-6596 | EISSN: | 1422-0067 | DOI: | 10.3390/ijms22041850 | Rights: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). The following publication Tam, W. Y., Wang, X., Cheng, A. S., & Cheung, K. K. (2021). In Search of Molecular Markers for Cerebellar Neurons. International Journal of Molecular Sciences, 22(4), 1850, 1-11 is availiable at https://doi.org10.3390/ijms22041850 |
| Appears in Collections: | Journal/Magazine Article |
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| ijms-22-01850-v2.pdf | 3.03 MB | Adobe PDF | View/Open |
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