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Title: Immune complexes impaired glomerular endothelial cell functions in lupus nephritis
Authors: Wang, LL 
Law, HKW 
Issue Date: 2019
Source: International journal of molecular sciences, 24 Oct. 2019, v. 20, no. 21, 5281, p. 1-16
Abstract: Lupus nephritis (LN) is one of the most common and severe complications of lupus. However, the mechanisms for renal damage have not been well elucidated. There are evidences show that glomerular endothelial cells (GECs) are damaged in LN. Immune complexes can deposit in subendothelial area and could affect GEC functions. In the present study, we used heat-aggregated gamma globulin (HAGG) to simulate immune complexes and investigated their effects on GEC functions. Our results revealed that HAGG impaired different aspect of the GEC functions. HAGG changed cell morphology, upregulated the expression of active caspase-3, inhibited angiogenesis, and increased NO production in GECs. These results provide new clues for the mechanisms of renal damage and the pathology of LN.
Keywords: Immune complexes
Glomerular endothelial cells functions
Lupus nephritis
Publisher: Molecular Diversity Preservation International (MDPI)
Journal: International journal of molecular sciences 
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms20215281
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
The following publication Wang, L.; Law, H.K.W. Immune Complexes Impaired Glomerular Endothelial Cell Functions in Lupus Nephritis. Int. J. Mol. Sci. 2019, 20, 5281, 1-16 is available at
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