Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/81770
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Wang, LL | - |
dc.creator | Law, HKW | - |
dc.date.accessioned | 2020-02-10T12:29:05Z | - |
dc.date.available | 2020-02-10T12:29:05Z | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10397/81770 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) | en_US |
dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Wang, L.; Law, H.K.W. Immune Complexes Impaired Glomerular Endothelial Cell Functions in Lupus Nephritis. Int. J. Mol. Sci. 2019, 20, 5281, 1-16 is available at https://dx.doi.org/10.3390/ijms20215281 | en_US |
dc.subject | Immune complexes | en_US |
dc.subject | Glomerular endothelial cells functions | en_US |
dc.subject | Lupus nephritis | en_US |
dc.title | Immune complexes impaired glomerular endothelial cell functions in lupus nephritis | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 16 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 21 | - |
dc.identifier.doi | 10.3390/ijms20215281 | - |
dcterms.abstract | Lupus nephritis (LN) is one of the most common and severe complications of lupus. However, the mechanisms for renal damage have not been well elucidated. There are evidences show that glomerular endothelial cells (GECs) are damaged in LN. Immune complexes can deposit in subendothelial area and could affect GEC functions. In the present study, we used heat-aggregated gamma globulin (HAGG) to simulate immune complexes and investigated their effects on GEC functions. Our results revealed that HAGG impaired different aspect of the GEC functions. HAGG changed cell morphology, upregulated the expression of active caspase-3, inhibited angiogenesis, and increased NO production in GECs. These results provide new clues for the mechanisms of renal damage and the pathology of LN. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | International journal of molecular sciences, 24 Oct. 2019, v. 20, no. 21, 5281, p. 1-16 | - |
dcterms.isPartOf | International journal of molecular sciences | - |
dcterms.issued | 2019 | - |
dc.identifier.isi | WOS:000498946100039 | - |
dc.identifier.scopus | 2-s2.0-85074132912 | - |
dc.identifier.pmid | 31652980 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.artn | 5281 | - |
dc.description.validate | 202002 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Wang_Immune_Complexes_Impaired.pdf | 3.98 MB | Adobe PDF | View/Open |
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