Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81770
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dc.contributorDepartment of Health Technology and Informatics-
dc.creatorWang, LL-
dc.creatorLaw, HKW-
dc.date.accessioned2020-02-10T12:29:05Z-
dc.date.available2020-02-10T12:29:05Z-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10397/81770-
dc.language.isoenen_US
dc.publisherMolecular Diversity Preservation International (MDPI)en_US
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.rightsThe following publication Wang, L.; Law, H.K.W. Immune Complexes Impaired Glomerular Endothelial Cell Functions in Lupus Nephritis. Int. J. Mol. Sci. 2019, 20, 5281, 1-16 is available at https://dx.doi.org/10.3390/ijms20215281en_US
dc.subjectImmune complexesen_US
dc.subjectGlomerular endothelial cells functionsen_US
dc.subjectLupus nephritisen_US
dc.titleImmune complexes impaired glomerular endothelial cell functions in lupus nephritisen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1-
dc.identifier.epage16-
dc.identifier.volume20-
dc.identifier.issue21-
dc.identifier.doi10.3390/ijms20215281-
dcterms.abstractLupus nephritis (LN) is one of the most common and severe complications of lupus. However, the mechanisms for renal damage have not been well elucidated. There are evidences show that glomerular endothelial cells (GECs) are damaged in LN. Immune complexes can deposit in subendothelial area and could affect GEC functions. In the present study, we used heat-aggregated gamma globulin (HAGG) to simulate immune complexes and investigated their effects on GEC functions. Our results revealed that HAGG impaired different aspect of the GEC functions. HAGG changed cell morphology, upregulated the expression of active caspase-3, inhibited angiogenesis, and increased NO production in GECs. These results provide new clues for the mechanisms of renal damage and the pathology of LN.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationInternational journal of molecular sciences, 24 Oct. 2019, v. 20, no. 21, 5281, p. 1-16-
dcterms.isPartOfInternational journal of molecular sciences-
dcterms.issued2019-
dc.identifier.isiWOS:000498946100039-
dc.identifier.scopus2-s2.0-85074132912-
dc.identifier.pmid31652980-
dc.identifier.eissn1422-0067-
dc.identifier.artn5281-
dc.description.validate202002 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.pubStatusPublisheden_US
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