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http://hdl.handle.net/10397/81650
| Title: | A brief overview of lncRNAs in endothelial dysfunction-associated diseases : from discovery to characterization | Authors: | Islam, R Lai, C |
Issue Date: | 2019 | Source: | Epigenomes, Sept. 2019, v. 3, no. 3, 20, p. 1-33 | Abstract: | Long non-coding RNAs (lncRNAs) are a novel class of regulatory RNA molecules and they are involved in many biological processes and disease developments. Several unique features of lncRNAs have been identified, such as tissue-and/or cell-specific expression pattern, which suggest that they could be potential candidates for therapeutic and diagnostic applications. More recently, the scope of 1ncRNA studies has been extended to endothelial biology research. Many of lncRNAs were found to be critically involved in the regulation of endothelial function and its associated disease progression. An improved understanding of endothelial biology can thus facilitate the discovery of novel biomarkers and therapeutic targets for endothelial dysfunction-associated diseases, such as abnormal angiogenesis, hypertension, diabetes, and atherosclerosis. Nevertheless, the underlying mechanism of lncRNA remains undefined in previous published studies. Therefore, in this review, we aimed to discuss the current methodologies for discovering and investigating the functions of lncRNAs and, in particular, to address the functions of selected lncRNAs in endothelial dysfunction-associated diseases. | Keywords: | Endothelial dysfunction LncRNAs Angiogenesis Hypertension Atherosclerosis Diabetes |
Publisher: | Molecular Diversity Preservation International (MDPI) | Journal: | Epigenomes | EISSN: | 2075-4655 | DOI: | 10.3390/epigenomes3030020 | Rights: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). The following publication Islam, R.; Lai, C. A Brief Overview of lncRNAs in Endothelial Dysfunction-Associated Diseases: From Discovery to Characterization. Epigenomes 2019, 3, 20, 1-33 is available at https://dx.doi.org/10.3390/epigenomes3030020 |
| Appears in Collections: | Journal/Magazine Article |
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| Islam_LncRNAs_Endothelial_Dysfunction-Associated.pdf | 1.38 MB | Adobe PDF | View/Open |
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