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http://hdl.handle.net/10397/77566
| Title: | FABP4 as a biomarker for knee osteoarthritis | Authors: | Zhang, C Li, T Chiu, KY Wen, C Xu, A Yan, CH |
Issue Date: | Feb-2018 | Source: | Biomarkers in medicine, Feb. 2018, v. 12, no. 2, p. 107-118 | Abstract: | Aim: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). Methods: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA. Results: Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29). FABP4 level of IPFP was positively correlated with SF FABP4. Conclusion: OA patients had significantly high systemic and local FABP4, and IPFP may be the main source of FABP4 in synovial cavity. FABP4 may be a promising biomarker for OA. | Keywords: | FABP4 Infrapatellar fat pad Osteoarthritis |
Publisher: | Future Medicine Ltd. | Journal: | Biomarkers in medicine | ISSN: | 1752-0363 | EISSN: | 1752-0371 | DOI: | 10.2217/bmm-2017-0207 | Rights: | © 2018 Future Medicine Ltd This is the peer reviewed version of the following article: Zhang, C., Li, T., Chiu, K. Y., Wen, C., Xu, A., & Yan, C. H. (2018). FABP4 as a biomarker for knee osteoarthritis. Biomarkers in medicine, 12(2), 107-118, which has been published in final form at https://doi.org/10.2217/bmm-2017-0207 |
| Appears in Collections: | Journal/Magazine Article |
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| Zhang_FABP4_Biomarker_Knee.pdf | Pre-Published version | 696.54 kB | Adobe PDF | View/Open |
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