Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/77566
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dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorZhang, Cen_US
dc.creatorLi, Ten_US
dc.creatorChiu, KYen_US
dc.creatorWen, Cen_US
dc.creatorXu, Aen_US
dc.creatorYan, CHen_US
dc.date.accessioned2018-08-28T01:33:16Z-
dc.date.available2018-08-28T01:33:16Z-
dc.identifier.issn1752-0363en_US
dc.identifier.urihttp://hdl.handle.net/10397/77566-
dc.language.isoenen_US
dc.publisherFuture Medicine Ltd.en_US
dc.rights© 2018 Future Medicine Ltden_US
dc.rightsThis is the peer reviewed version of the following article: Zhang, C., Li, T., Chiu, K. Y., Wen, C., Xu, A., & Yan, C. H. (2018). FABP4 as a biomarker for knee osteoarthritis. Biomarkers in medicine, 12(2), 107-118, which has been published in final form at https://doi.org/10.2217/bmm-2017-0207en_US
dc.subjectFABP4en_US
dc.subjectInfrapatellar fat paden_US
dc.subjectOsteoarthritisen_US
dc.titleFABP4 as a biomarker for knee osteoarthritisen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage107en_US
dc.identifier.epage118en_US
dc.identifier.volume12en_US
dc.identifier.issue2en_US
dc.identifier.doi10.2217/bmm-2017-0207en_US
dcterms.abstractAim: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). Methods: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA. Results: Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29). FABP4 level of IPFP was positively correlated with SF FABP4. Conclusion: OA patients had significantly high systemic and local FABP4, and IPFP may be the main source of FABP4 in synovial cavity. FABP4 may be a promising biomarker for OA.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationBiomarkers in medicine, Feb. 2018, v. 12, no. 2, p. 107-118en_US
dcterms.isPartOfBiomarkers in medicineen_US
dcterms.issued2018-02-
dc.identifier.isiWOS:000424013300004-
dc.identifier.scopus2-s2.0-85041399149-
dc.identifier.eissn1752-0371en_US
dc.identifier.rosgroupid2017000557-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validate201808 bcrcen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumberBME-0166-
dc.description.fundingSourceOthersen_US
dc.description.fundingTextShenzhen Science and Technology Fundingen_US
dc.description.pubStatusPublisheden_US
dc.identifier.OPUS14782852-
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