Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/77566
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Zhang, C | en_US |
dc.creator | Li, T | en_US |
dc.creator | Chiu, KY | en_US |
dc.creator | Wen, C | en_US |
dc.creator | Xu, A | en_US |
dc.creator | Yan, CH | en_US |
dc.date.accessioned | 2018-08-28T01:33:16Z | - |
dc.date.available | 2018-08-28T01:33:16Z | - |
dc.identifier.issn | 1752-0363 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/77566 | - |
dc.language.iso | en | en_US |
dc.publisher | Future Medicine Ltd. | en_US |
dc.rights | © 2018 Future Medicine Ltd | en_US |
dc.rights | This is the peer reviewed version of the following article: Zhang, C., Li, T., Chiu, K. Y., Wen, C., Xu, A., & Yan, C. H. (2018). FABP4 as a biomarker for knee osteoarthritis. Biomarkers in medicine, 12(2), 107-118, which has been published in final form at https://doi.org/10.2217/bmm-2017-0207 | en_US |
dc.subject | FABP4 | en_US |
dc.subject | Infrapatellar fat pad | en_US |
dc.subject | Osteoarthritis | en_US |
dc.title | FABP4 as a biomarker for knee osteoarthritis | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 107 | en_US |
dc.identifier.epage | 118 | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.doi | 10.2217/bmm-2017-0207 | en_US |
dcterms.abstract | Aim: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). Methods: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA. Results: Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29). FABP4 level of IPFP was positively correlated with SF FABP4. Conclusion: OA patients had significantly high systemic and local FABP4, and IPFP may be the main source of FABP4 in synovial cavity. FABP4 may be a promising biomarker for OA. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Biomarkers in medicine, Feb. 2018, v. 12, no. 2, p. 107-118 | en_US |
dcterms.isPartOf | Biomarkers in medicine | en_US |
dcterms.issued | 2018-02 | - |
dc.identifier.isi | WOS:000424013300004 | - |
dc.identifier.scopus | 2-s2.0-85041399149 | - |
dc.identifier.eissn | 1752-0371 | en_US |
dc.identifier.rosgroupid | 2017000557 | - |
dc.description.ros | 2017-2018 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.validate | 201808 bcrc | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | BME-0166 | - |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Shenzhen Science and Technology Funding | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 14782852 | - |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Zhang_FABP4_Biomarker_Knee.pdf | Pre-Published version | 696.54 kB | Adobe PDF | View/Open |
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