Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76208
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dc.contributorDepartment of Rehabilitation Sciences-
dc.creatorZhang, ZK-
dc.creatorGuo, X-
dc.creatorLao, J-
dc.creatorQin, YX-
dc.date.accessioned2018-05-10T02:55:33Z-
dc.date.available2018-05-10T02:55:33Z-
dc.identifier.issn2214-031X-
dc.identifier.urihttp://hdl.handle.net/10397/76208-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2017 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectBoneen_US
dc.subjectCapsaicinen_US
dc.subjectHindlimb suspensionen_US
dc.subjectSensory neuronen_US
dc.titleEffect of capsaicin-sensitive sensory neurons on bone architecture and mechanical properties in the rat hindlimb suspension modelen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage12-
dc.identifier.epage17-
dc.identifier.volume10-
dc.identifier.doi10.1016/j.jot.2017.03.001-
dcterms.abstractBackground/Objective: The participation of sensory neural regulation in bone metabolism has been widely studied. However, the physiological role of sensory neural regulation in the functional adaptation to weight bearing is not clear. This study was conducted to investigate the effect of capsaicin-induced sensory neuron lesions on cancellous architecture properties in a hindlimb suspension (HLS) model. Methods: Thirty-two female rats were randomly assigned to four groups. Groups b and d underwent systemic capsaicin treatment, whereas Groups a and c were treated with vehicle. Then, Groups c and d were subjected to HLS, whereas Groups a and b were allowed hindlimbs full loading. The proximal trabecular and mid-shaft cortical bone structure were evaluated via microcomputed tomography, and the biomechanical properties of the tibial mid-shaft were assessed using the four-point bending test. Results: The trabecular bone volume was reduced by 40% and 50% in Groups b and c, respectively, and was also reduced significantly in Group d. Trabecular thickness and trabecular separation in Group b were not significantly different from those of Group a. The cortical bone area fraction showed no significant difference among all groups. Compared with Group a, the ultimate strength in Group b decreased by 20.3%, whereas it did not change significantly in Group c. Conclusion: The results suggest that capsaicin-sensitive sensory neurons play an important role in bone modelling. The effect of capsaicin is similar to HLS. However, HLS has no add-on effect to capsaicin in the reduction of bone density and mechanical properties. Translational potential of this article: This study gives clues to the function of sensory neurons in bone modelling.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationJournal of orthopaedic translation, 2017, v. 10, special issue SI, p. 12-17-
dcterms.isPartOfJournal of orthopaedic translation-
dcterms.issued2017-
dc.identifier.isiWOS:000406877300004-
dc.identifier.rosgroupid2017004032-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journal-
dc.description.validate201805 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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