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Title: High-frequency ultrasound imaging of tidemark in vitro in advanced knee osteoarthritis
Authors: Huang, YP 
Zhong, J 
Chen, J 
Yan, CH
Zheng, YP 
Wen, CY 
Issue Date: Jan-2018
Source: Ultrasound in medicine and biology, Jan. 2018, v. 44, no. 1, p. 94-101
Abstract: High-frequency ultrasound imaging has been widely adopted for assessment of the degenerative changes of articular cartilage in osteoarthritis (OA). Yet, there are few reports on investigating its capability to evaluate subchondral bone. Here, we employed high-frequency ultrasound imaging (25 MHz) to examine in vitro the tidemark in cylindrical osteochondral disks (n = 33) harvested from advanced OA knees of humans. We found good correspondence in morphology observed by ultrasound imaging and micro-computed tomography. Ultrasound roughness index (URI) of tidemark was derived from the raw radiofrequency signals to compare with bone quality factors, including bone volume fraction (BV/TV) and bone mineral density (BMD) measured by micro-computed tomography, using the Spearman correlation (ρ). URI of the tidemark was negatively associated with the subchondral plate BV/TV (ρ = -0.73, p <. 0.001), BMD (ρ = -0.40, p = 0.020), as well as the underneath trabecular bone BV/TV (ρ = -0.39, p = 0.025) and BMD (ρ = -0.43, p = 0.012). In conclusion, this preliminary study demonstrated that morphology measured by high-frequency ultrasound imaging could reflect the quality of the subchondral bone. High-frequency ultrasound is a promising imaging tool to evaluate the changes of the subchondral bone in addition to those of the overlying cartilage in OA.
Keywords: Articular cartilage
High-frequency ultrasound
Subchondral bone
Publisher: Elsevier
Journal: Ultrasound in medicine and biology 
ISSN: 0301-5629
EISSN: 1879-291X
DOI: 10.1016/j.ultrasmedbio.2017.08.1884
Rights: Copyright © 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
The following publication Huang, Y. P., Zhong, J., Chen, J., Yan, C. H., Zheng, Y. P., & Wen, C. Y. (2018). High-frequency ultrasound imaging of tidemark in vitro in advanced knee osteoarthritis. Ultrasound in Medicine & Biology, 44(1), 94-101 is available at
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