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http://hdl.handle.net/10397/74494
| Title: | Ultrasonic characteristics and cellular properties of Anabaena gas vesicles | Authors: | Yang, Y Qiu, Z Hou, X Sun, L |
Issue Date: | Dec-2017 | Source: | Ultrasound in medicine and biology, Dec. 2017, v. 43, no. 12, p. 2862-2870 | Abstract: | Ultrasound imaging is a common modality in clinical examination and biomedical research, but has not played a significant role in molecular imaging for lack of an appropriate contrast agent. Recently, biogenic gas vesicles (GVs), naturally formed by cyanobacteria and haloarchaea, have exhibited great potential as an ultrasound molecular imaging probe with a much smaller size (∼100 nm) and improved imaging contrast. However, the basic acoustic and biological properties of GVs remain unclear, which hinders future application. Here, we studied the fundamental acoustic properties of a rod-shaped gas vesicle from Anabaena, a kind of cyanobacterium, including attenuation, oscillation resonance, and scattering, as well as biological behaviors (cellular internalization and cytotoxicity). We found that GVs have two resonance peaks (85 and 120 MHz). We also observed a significant non-linear effect and its pressure dependence as well. Ultrasound B-mode imaging reveals sufficient echogenicity of GVs for ultrasound imaging enhancement at high frequencies. Biological characterization also reveals endocytosis and non-toxicity. | Keywords: | Acoustic characterization Contrast agent Gas vesicle Molecular imaging Nanobubble Resonance frequency Scattering property Ultrasound |
Publisher: | Elsevier | Journal: | Ultrasound in medicine and biology | ISSN: | 0301-5629 | EISSN: | 1879-291X | DOI: | 10.1016/j.ultrasmedbio.2017.08.004 | Rights: | Copyright © 2017 World Federation for Ultrasound in Medicine & Biology. All rights reserved. © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ The following publication Yang, Y., Qiu, Z., Hou, X., & Sun, L. (2017). Ultrasonic characteristics and cellular properties of Anabaena gas vesicles. Ultrasound in medicine & biology, 43(12), 2862-2870 is available at https://doi.org/10.1016/j.ultrasmedbio.2017.08.004 |
| Appears in Collections: | Journal/Magazine Article |
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