Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/74494
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dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorYang, Yen_US
dc.creatorQiu, Zen_US
dc.creatorHou, Xen_US
dc.creatorSun, Len_US
dc.date.accessioned2018-03-29T07:16:57Z-
dc.date.available2018-03-29T07:16:57Z-
dc.identifier.issn0301-5629en_US
dc.identifier.urihttp://hdl.handle.net/10397/74494-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsCopyright © 2017 World Federation for Ultrasound in Medicine & Biology. All rights reserved.en_US
dc.rights© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.rightsThe following publication Yang, Y., Qiu, Z., Hou, X., & Sun, L. (2017). Ultrasonic characteristics and cellular properties of Anabaena gas vesicles. Ultrasound in medicine & biology, 43(12), 2862-2870 is available at https://doi.org/10.1016/j.ultrasmedbio.2017.08.004en_US
dc.subjectAcoustic characterizationen_US
dc.subjectContrast agenten_US
dc.subjectGas vesicleen_US
dc.subjectMolecular imagingen_US
dc.subjectNanobubbleen_US
dc.subjectResonance frequencyen_US
dc.subjectScattering propertyen_US
dc.subjectUltrasounden_US
dc.titleUltrasonic characteristics and cellular properties of Anabaena gas vesiclesen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage2862en_US
dc.identifier.epage2870en_US
dc.identifier.volume43en_US
dc.identifier.issue12en_US
dc.identifier.doi10.1016/j.ultrasmedbio.2017.08.004en_US
dcterms.abstractUltrasound imaging is a common modality in clinical examination and biomedical research, but has not played a significant role in molecular imaging for lack of an appropriate contrast agent. Recently, biogenic gas vesicles (GVs), naturally formed by cyanobacteria and haloarchaea, have exhibited great potential as an ultrasound molecular imaging probe with a much smaller size (∼100 nm) and improved imaging contrast. However, the basic acoustic and biological properties of GVs remain unclear, which hinders future application. Here, we studied the fundamental acoustic properties of a rod-shaped gas vesicle from Anabaena, a kind of cyanobacterium, including attenuation, oscillation resonance, and scattering, as well as biological behaviors (cellular internalization and cytotoxicity). We found that GVs have two resonance peaks (85 and 120 MHz). We also observed a significant non-linear effect and its pressure dependence as well. Ultrasound B-mode imaging reveals sufficient echogenicity of GVs for ultrasound imaging enhancement at high frequencies. Biological characterization also reveals endocytosis and non-toxicity.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationUltrasound in medicine and biology, Dec. 2017, v. 43, no. 12, p. 2862-2870en_US
dcterms.isPartOfUltrasound in medicine and biologyen_US
dcterms.issued2017-12-
dc.identifier.isiWOS:000415604700012-
dc.identifier.scopus2-s2.0-85032179748-
dc.identifier.ros2017000517-
dc.identifier.eissn1879-291Xen_US
dc.identifier.rosgroupid2017000515-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validate201802 bcrcen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumberBME-0177-
dc.description.fundingSourceRGCen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextHong Kong Research Grant Council; National Natural Science Foundations of Chinaen_US
dc.description.pubStatusPublisheden_US
dc.identifier.OPUS6791420-
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