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Title: Pain controlling and cytokine-regulating effects of lyprinol, a lipid extract of perna canaliculus, in a rat adjuvant-induced arthritis model
Authors: Lee, CH
Lum, HK
Ng, CKC
McKay, J
Butt, YKC
Wong, MS 
Lo, SCL 
Issue Date: 2009
Source: Evidence-based complementary and alternative medicine, 2009, v. 6, no. 2, p. 239-245
Abstract: Using an adjuvant-induced arthritis rat model, we investigated the effects of a lipid extract of Perna canaliculus (Lyprinol®) on pain. Radiological examinations, as well as levels of pro- and anti-inflammatory (AI) cytokines, were measured aiming to provide independent objective data to the pain controlling investigation. We confirmed the ability of Lyprinol® to control pain at the initial phase of its administration; with similar efficacy to that observed with Naproxen. The pain scores slowly increased again in the group of rats treated with Lyprinol® after day 9–14. The Naproxen-treated rats remained pain-free while treated. Both Naproxen and Lyprinol® decreased the levels of the pro-inflammatory cytokines TNF-α and IFN-γ, and increased that of IL-10. Extra-virgin olive oil was ineffective on cytokine secretion. Rats treated with Lyprinol® were apparently cured after 1 year. This study confirms the AI efficacy of this lipid extract of P. canaliculus, its initial analgesic effect, its perfect tolerance and its long-term healing properties.
Keywords: Adjuvant-induced arthritis
Inflammatory cytokines
Lyprinol
NZGLM
Pain score
Publisher: Hindawi Publishing Corporation
Journal: Evidence-based complementary and alternative medicine 
ISSN: 1741-427X
EISSN: 1741-4288
DOI: 10.1093/ecam/nem100
Rights: Copyright © 2009 Chi-Ho Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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