Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/6845
PIRA download icon_1.1View/Download Full Text
DC FieldValueLanguage
dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.contributorDepartment of Health Technology and Informatics-
dc.creatorLee, CH-
dc.creatorLum, HK-
dc.creatorNg, CKC-
dc.creatorMcKay, J-
dc.creatorButt, YKC-
dc.creatorWong, MS-
dc.creatorLo, SCL-
dc.date.accessioned2014-12-11T08:25:40Z-
dc.date.available2014-12-11T08:25:40Z-
dc.identifier.issn1741-427X-
dc.identifier.urihttp://hdl.handle.net/10397/6845-
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.rightsCopyright © 2009 Chi-Ho Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights© 2007 The Author(s).en_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectAdjuvant-induced arthritisen_US
dc.subjectInflammatory cytokinesen_US
dc.subjectLyprinolen_US
dc.subjectNZGLMen_US
dc.subjectPain scoreen_US
dc.titlePain controlling and cytokine-regulating effects of lyprinol, a lipid extract of perna canaliculus, in a rat adjuvant-induced arthritis modelen_US
dc.typeJournal/Magazine Articleen_US
dc.description.otherinformationAuthor name used in this publication: John Hon-Kei Lumen_US
dc.description.otherinformationAuthor name used in this publication: Samuel Chun-Lap Loen_US
dc.identifier.spage239-
dc.identifier.epage245-
dc.identifier.volume6-
dc.identifier.issue2-
dc.identifier.doi10.1093/ecam/nem100-
dcterms.abstractUsing an adjuvant-induced arthritis rat model, we investigated the effects of a lipid extract of Perna canaliculus (Lyprinol®) on pain. Radiological examinations, as well as levels of pro- and anti-inflammatory (AI) cytokines, were measured aiming to provide independent objective data to the pain controlling investigation. We confirmed the ability of Lyprinol® to control pain at the initial phase of its administration; with similar efficacy to that observed with Naproxen. The pain scores slowly increased again in the group of rats treated with Lyprinol® after day 9–14. The Naproxen-treated rats remained pain-free while treated. Both Naproxen and Lyprinol® decreased the levels of the pro-inflammatory cytokines TNF-α and IFN-γ, and increased that of IL-10. Extra-virgin olive oil was ineffective on cytokine secretion. Rats treated with Lyprinol® were apparently cured after 1 year. This study confirms the AI efficacy of this lipid extract of P. canaliculus, its initial analgesic effect, its perfect tolerance and its long-term healing properties.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationEvidence-based complementary and alternative medicine, 2009, v. 6, no. 2, p. 239-245-
dcterms.isPartOfEvidence-based complementary and alternative medicine-
dcterms.issued2009-
dc.identifier.isiWOS:000266498500015-
dc.identifier.scopus2-s2.0-70349522007-
dc.identifier.pmid18955235-
dc.identifier.eissn1741-4288-
dc.identifier.rosgroupidr41222-
dc.description.ros2008-2009 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
Appears in Collections:Journal/Magazine Article
Files in This Item:
File Description SizeFormat 
Lee_Pain_Cytokine-Regulating_Lyprinol.pdf160.02 kBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show simple item record

Page views

115
Last Week
3
Last month
Citations as of Jun 26, 2022

Downloads

47
Citations as of Jun 26, 2022

SCOPUSTM   
Citations

15
Last Week
0
Last month
1
Citations as of Jun 23, 2022

WEB OF SCIENCETM
Citations

14
Last Week
0
Last month
1
Citations as of Jun 23, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.