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http://hdl.handle.net/10397/36208
| Title: | Cortex Fraxini (Qingpi) protects Rat Pheochromocytoma cells against 6-Hydroxydopamine-induced Apoptosis | Authors: | Li, JJ Zhou, SY Zhang, H Lam, KH Lee, SMY Yu, PHF Chan, SW |
Issue Date: | 2015 | Source: | Parkinson's disease, 2015, 532849 | Abstract: | Parkinson's disease (PD) is a chronic neurodegenerative disorder having close relationship with oxidative stress induced by reactive oxygen species (ROS). Cortex Fraxini (QP) is a kind of traditional Chinese medicinal herb with antioxidant properties. It may be a potential candidate for preventing the development of chronic neurodegenerative diseases. Thus, the key objective of the current study was to investigate the neuroprotective effect of QP water extract on 6-hydroxydopamine (6-OHDA) induced apoptosis in rat pheochromocytoma (PC12) cells. It was found that QP water extract possesses strong antioxidant property with SC50 = 0.15 mg/mL. Total phenolic content of QP water extract was found to be 200.78 +/- 2.65 mg GAE/g. QP water extract's free radical scavenging capacity was demonstrated by reversing the increased level of intracellular ROS induced by 6-OHDA, using 2',7'-dichlorodihydrofluorescein diacetate. Moreover, QP water extract (0.5mg/mL) could remarkably increase the viability of PC12 cells treated with 6-OHDA. The protective effect of QP water extract was found to be via inhibiting MEK/ERK pathway and reversing PI3-K/Akt/GSK3 beta pathway. The current results suggest that QP might be a potential candidate for preventing the development of neurodegenerative diseases, such as PD. | Publisher: | Hindawi Publishing Corporation | Journal: | Parkinson's disease | ISSN: | 2090-8083 | EISSN: | 2042-0080 | DOI: | 10.1155/2015/532849 | Rights: | Copyright © 2015 Jing-Jie Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The following article: Li, J. J., Zhou, S. Y., Zhang, H., Lam, K. H., Lee, S. M. Y., Yu, P. H. F., & Chan, S. W. (2015). Cortex Fraxini (Qingpi) protects rat pheochromocytoma cells against 6-hydroxydopamine-induced apoptosis. Parkinson’s Disease, 2015, is available at https//doi.org/10.1155/2015/532849 |
| Appears in Collections: | Journal/Magazine Article |
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