Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/36208
PIRA download icon_1.1View/Download Full Text
DC FieldValueLanguage
dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorLi, JJ-
dc.creatorZhou, SY-
dc.creatorZhang, H-
dc.creatorLam, KH-
dc.creatorLee, SMY-
dc.creatorYu, PHF-
dc.creatorChan, SW-
dc.date.accessioned2016-04-15T08:36:46Z-
dc.date.available2016-04-15T08:36:46Z-
dc.identifier.issn2090-8083en_US
dc.identifier.urihttp://hdl.handle.net/10397/36208-
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.rightsCopyright © 2015 Jing-Jie Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rightsThe following article: Li, J. J., Zhou, S. Y., Zhang, H., Lam, K. H., Lee, S. M. Y., Yu, P. H. F., & Chan, S. W. (2015). Cortex Fraxini (Qingpi) protects rat pheochromocytoma cells against 6-hydroxydopamine-induced apoptosis. Parkinson’s Disease, 2015, is available at https//doi.org/10.1155/2015/532849en_US
dc.titleCortex Fraxini (Qingpi) protects Rat Pheochromocytoma cells against 6-Hydroxydopamine-induced Apoptosisen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.doi10.1155/2015/532849en_US
dcterms.abstractParkinson's disease (PD) is a chronic neurodegenerative disorder having close relationship with oxidative stress induced by reactive oxygen species (ROS). Cortex Fraxini (QP) is a kind of traditional Chinese medicinal herb with antioxidant properties. It may be a potential candidate for preventing the development of chronic neurodegenerative diseases. Thus, the key objective of the current study was to investigate the neuroprotective effect of QP water extract on 6-hydroxydopamine (6-OHDA) induced apoptosis in rat pheochromocytoma (PC12) cells. It was found that QP water extract possesses strong antioxidant property with SC50 = 0.15 mg/mL. Total phenolic content of QP water extract was found to be 200.78 +/- 2.65 mg GAE/g. QP water extract's free radical scavenging capacity was demonstrated by reversing the increased level of intracellular ROS induced by 6-OHDA, using 2',7'-dichlorodihydrofluorescein diacetate. Moreover, QP water extract (0.5mg/mL) could remarkably increase the viability of PC12 cells treated with 6-OHDA. The protective effect of QP water extract was found to be via inhibiting MEK/ERK pathway and reversing PI3-K/Akt/GSK3 beta pathway. The current results suggest that QP might be a potential candidate for preventing the development of neurodegenerative diseases, such as PD.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationParkinson's disease, 2015, 532849-
dcterms.isPartOfParkinson's disease-
dcterms.issued2015-
dc.identifier.isiWOS:000360145700001-
dc.identifier.scopus2-s2.0-84940416429-
dc.identifier.eissn2042-0080en_US
dc.identifier.rosgroupid2014005048-
dc.description.ros2014-2015 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validatebcsmen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
Appears in Collections:Journal/Magazine Article
Files in This Item:
File Description SizeFormat 
Li_Cortex_Fraxini_Qingpi.pdf2.81 MBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show simple item record

Page views

132
Last Week
3
Last month
Citations as of Mar 24, 2024

Downloads

103
Citations as of Mar 24, 2024

SCOPUSTM   
Citations

12
Last Week
0
Last month
Citations as of Mar 28, 2024

WEB OF SCIENCETM
Citations

8
Last Week
0
Last month
Citations as of Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.