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Title: Tracer kinetic modeling of ¹¹C-acetate applied in the liver with positron emission tomography
Authors: Chen, S
Ho, C
Feng, DD
Chi, ZG 
Issue Date: Apr-2004
Source: IEEE transactions on medical imaging, Apr. 2004, v. 23, no. 4, p. 426-432
Abstract: It is well known that 40%-50% of hepatocellular carcinoma (HCC) do not show increased [sup 18]F-fluorodeoxyglucose (FDG) uptake. Recent research studies have demonstrated that ¹¹C-acetate may be a complementary tracer to FDG in positron emission tomography (PET) imaging of HCC in the liver. Quantitative dynamic modeling is, therefore, conducted to evaluate the kinetic characteristics of this tracer in HCC and nontumor liver tissue. A three-compartment model consisting of four parameters with dual inputs is proposed and compared with that of five parameters. Twelve regions of dynamic datasets of the liver extracted from six patients are used to test the models. Estimation of the adequacy of these models is based on Akaike Information Criteria (AIC) and Schwarz Criteria (SC) by statistical study. The forward clearance K=K₁﹡k₃/(k₂+k₃) is estimated and defined as a new parameter called the local hepatic metabolic rate-constant of acetate (LHMRAct) using both the weighted nonlinear least squares (NLS) and the linear Patlak methods. Preliminary results show that the LHMRAct of the HCC is significantly higher than that of the nontumor liver tissue. These model parameters provide quantitative evidence and understanding on the kinetic basis of ¹¹C-acetate for its potential role in the imaging of HCC using PET.
Keywords: Local hepatic metabolic rate-constant of acetate (LHMRAct)
Parameter estimation
Positron emission tomography (PET)
Publisher: Institute of Electrical and Electronics Engineers
Journal: IEEE transactions on medical imaging 
ISSN: 0278-0062 (print)
1558-254X (online)
DOI: 10.1109/TMI.2004.824229
Rights: © 2004 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
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