Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/1875
| Title: | Tracer kinetic modeling of ¹¹C-acetate applied in the liver with positron emission tomography | Authors: | Chen, S Ho, C Feng, DD Chi, ZG |
Issue Date: | Apr-2004 | Source: | IEEE transactions on medical imaging, Apr. 2004, v. 23, no. 4, p. 426-432 | Abstract: | It is well known that 40%-50% of hepatocellular carcinoma (HCC) do not show increased [sup 18]F-fluorodeoxyglucose (FDG) uptake. Recent research studies have demonstrated that ¹¹C-acetate may be a complementary tracer to FDG in positron emission tomography (PET) imaging of HCC in the liver. Quantitative dynamic modeling is, therefore, conducted to evaluate the kinetic characteristics of this tracer in HCC and nontumor liver tissue. A three-compartment model consisting of four parameters with dual inputs is proposed and compared with that of five parameters. Twelve regions of dynamic datasets of the liver extracted from six patients are used to test the models. Estimation of the adequacy of these models is based on Akaike Information Criteria (AIC) and Schwarz Criteria (SC) by statistical study. The forward clearance K=K₁﹡k₃/(k₂+k₃) is estimated and defined as a new parameter called the local hepatic metabolic rate-constant of acetate (LHMRAct) using both the weighted nonlinear least squares (NLS) and the linear Patlak methods. Preliminary results show that the LHMRAct of the HCC is significantly higher than that of the nontumor liver tissue. These model parameters provide quantitative evidence and understanding on the kinetic basis of ¹¹C-acetate for its potential role in the imaging of HCC using PET. | Keywords: | Local hepatic metabolic rate-constant of acetate (LHMRAct) Modeling Parameter estimation Positron emission tomography (PET) ¹¹C-acetate |
Publisher: | Institute of Electrical and Electronics Engineers | Journal: | IEEE transactions on medical imaging | ISSN: | 0278-0062 (print) 1558-254X (online) |
DOI: | 10.1109/TMI.2004.824229 | Rights: | © 2004 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. |
| Appears in Collections: | Journal/Magazine Article |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Chen_et_al_Tracer_Kinetic_Modeling.pdf | 294.06 kB | Adobe PDF | View/Open |
Access
View full-text via PolyU eLinks 
Page views
62
Last Week
0
0
Last month
Citations as of May 28, 2023
Downloads
112
Citations as of May 28, 2023
SCOPUSTM
Citations
35
Last Week
0
0
Last month
0
0
Citations as of May 25, 2023
WEB OF SCIENCETM
Citations
29
Last Week
0
0
Last month
0
0
Citations as of May 25, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.