Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/1875
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dc.contributorDepartment of Electronic and Information Engineering-
dc.creatorChen, S-
dc.creatorHo, C-
dc.creatorFeng, DD-
dc.creatorChi, ZG-
dc.date.accessioned2014-12-11T08:25:34Z-
dc.date.available2014-12-11T08:25:34Z-
dc.identifier.issn0278-0062 (print)-
dc.identifier.issn1558-254X (online)-
dc.identifier.urihttp://hdl.handle.net/10397/1875-
dc.language.isoenen_US
dc.publisherInstitute of Electrical and Electronics Engineersen_US
dc.rights© 2004 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.en_US
dc.rightsThis material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.en_US
dc.subjectLocal hepatic metabolic rate-constant of acetate (LHMRAct)en_US
dc.subjectModelingen_US
dc.subjectParameter estimationen_US
dc.subjectPositron emission tomography (PET)en_US
dc.subject¹¹C-acetateen_US
dc.titleTracer kinetic modeling of ¹¹C-acetate applied in the liver with positron emission tomographyen_US
dc.typeJournal/Magazine Articleen_US
dc.description.otherinformationAuthor name used in this publication: Dagan Fengen_US
dc.description.otherinformationAuthor name used in this publication: Zheru Chien_US
dc.description.otherinformationCentre for Multimedia Signal Processing, Department of Electronic and Information Engineeringen_US
dc.identifier.spage426-
dc.identifier.epage432-
dc.identifier.volume23-
dc.identifier.issue4-
dc.identifier.doi10.1109/TMI.2004.824229-
dcterms.abstractIt is well known that 40%-50% of hepatocellular carcinoma (HCC) do not show increased [sup 18]F-fluorodeoxyglucose (FDG) uptake. Recent research studies have demonstrated that ¹¹C-acetate may be a complementary tracer to FDG in positron emission tomography (PET) imaging of HCC in the liver. Quantitative dynamic modeling is, therefore, conducted to evaluate the kinetic characteristics of this tracer in HCC and nontumor liver tissue. A three-compartment model consisting of four parameters with dual inputs is proposed and compared with that of five parameters. Twelve regions of dynamic datasets of the liver extracted from six patients are used to test the models. Estimation of the adequacy of these models is based on Akaike Information Criteria (AIC) and Schwarz Criteria (SC) by statistical study. The forward clearance K=K₁﹡k₃/(k₂+k₃) is estimated and defined as a new parameter called the local hepatic metabolic rate-constant of acetate (LHMRAct) using both the weighted nonlinear least squares (NLS) and the linear Patlak methods. Preliminary results show that the LHMRAct of the HCC is significantly higher than that of the nontumor liver tissue. These model parameters provide quantitative evidence and understanding on the kinetic basis of ¹¹C-acetate for its potential role in the imaging of HCC using PET.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationIEEE transactions on medical imaging, Apr. 2004, v. 23, no. 4, p. 426-432-
dcterms.isPartOfIEEE transactions on medical imaging-
dcterms.issued2004-04-
dc.identifier.isiWOS:000220611800003-
dc.identifier.scopus2-s2.0-1942519687-
dc.identifier.pmid15084068-
dc.identifier.rosgroupidr17583-
dc.description.ros2003-2004 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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