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Title: | Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array | Authors: | Szarka, G Ganczer, A Balogh, M Tengölics, ÁJ Futácsi, A Kenyon, G Pan, F Kovács-Öller, T Völgyi, B |
Issue Date: | 2024 | Source: | iScience, Available online 24 May 2024, In Press, Journal Pre-proof, 110099 | Abstract: | Retinal ganglion cells (RGCs) summate inputs and forward a spike train code to the brain in the form of either maintained spiking (sustained) or a quickly decaying brief spike burst (transient). We report diverse response transience values across the RGC population and, contrary to the conventional transient/sustained scheme, responses with intermediary characteristics are the most abundant. Pharmacological tests showed that besides GABAergic inhibition, GJ mediated excitation also plays a pivotal role in shaping response transience and thus visual coding. More precisely GJs connecting RGCs to nearby amacrine and RGCs play a defining role in the process. These GJs equalize kinetic features, including the response transience of transient OFF alpha (tOFFα) RGCs across a coupled array. We propose that GJs in other coupled neuron ensembles in the brain are also critical in the harmonization of response kinetics to enhance the population code and suit a corresponding task. Graphical abstract: [Figure not available: see fulltext.] | Keywords: | Electrical synapse Ganglion cell Ganglion cell layer Gap junction Inner plexiform layer Parallel signaling Retina |
Publisher: | Cell Press | Journal: | iScience | EISSN: | 2589-0042 | DOI: | 10.1016/j.isci.2024.110099 |
Appears in Collections: | Journal/Magazine Article |
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