Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/106659
DC Field | Value | Language |
---|---|---|
dc.contributor | School of Optometry | en_US |
dc.creator | Szarka, G | en_US |
dc.creator | Ganczer, A | en_US |
dc.creator | Balogh, M | en_US |
dc.creator | Tengölics, ÁJ | en_US |
dc.creator | Futácsi, A | en_US |
dc.creator | Kenyon, G | en_US |
dc.creator | Pan, F | en_US |
dc.creator | Kovács-Öller, T | en_US |
dc.creator | Völgyi, B | en_US |
dc.date.accessioned | 2024-05-29T06:16:13Z | - |
dc.date.available | 2024-05-29T06:16:13Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/106659 | - |
dc.language.iso | en | en_US |
dc.publisher | Cell Press | en_US |
dc.subject | Electrical synapse | en_US |
dc.subject | Ganglion cell | en_US |
dc.subject | Ganglion cell layer | en_US |
dc.subject | Gap junction | en_US |
dc.subject | Inner plexiform layer | en_US |
dc.subject | Parallel signaling | en_US |
dc.subject | Retina | en_US |
dc.title | Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1016/j.isci.2024.110099 | en_US |
dcterms.abstract | Retinal ganglion cells (RGCs) summate inputs and forward a spike train code to the brain in the form of either maintained spiking (sustained) or a quickly decaying brief spike burst (transient). We report diverse response transience values across the RGC population and, contrary to the conventional transient/sustained scheme, responses with intermediary characteristics are the most abundant. Pharmacological tests showed that besides GABAergic inhibition, GJ mediated excitation also plays a pivotal role in shaping response transience and thus visual coding. More precisely GJs connecting RGCs to nearby amacrine and RGCs play a defining role in the process. These GJs equalize kinetic features, including the response transience of transient OFF alpha (tOFFα) RGCs across a coupled array. We propose that GJs in other coupled neuron ensembles in the brain are also critical in the harmonization of response kinetics to enhance the population code and suit a corresponding task. Graphical abstract: [Figure not available: see fulltext.] | en_US |
dcterms.accessRights | embargoed access | en_US |
dcterms.bibliographicCitation | iScience, Available online 24 May 2024, In Press, Journal Pre-proof, 110099 | en_US |
dcterms.isPartOf | iScience | en_US |
dcterms.issued | 2024 | - |
dc.identifier.eissn | 2589-0042 | en_US |
dc.identifier.artn | 110099 | en_US |
dc.description.validate | 202405 bcch | en_US |
dc.description.oa | Not applicable | en_US |
dc.identifier.FolderNumber | a2724 | - |
dc.identifier.SubFormID | 48124 | - |
dc.description.fundingSource | Self-funded | en_US |
dc.description.pubStatus | Early release | en_US |
dc.date.embargo | 0000-00-00 (to be updated) | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.