Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/106389
DC Field | Value | Language |
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dc.contributor | Department of Mechanical Engineering | - |
dc.creator | Cui, J | - |
dc.creator | Liu, Y | - |
dc.creator | Fu, BM | - |
dc.date.accessioned | 2024-05-09T00:53:10Z | - |
dc.date.available | 2024-05-09T00:53:10Z | - |
dc.identifier.issn | 1617-7959 | - |
dc.identifier.uri | http://hdl.handle.net/10397/106389 | - |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.rights | © Springer-Verlag GmbH Germany, part of Springer Nature 2019 | en_US |
dc.rights | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use(https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10237-019-01192-8. | en_US |
dc.subject | Fluid–structure interaction | en_US |
dc.subject | Immersed boundary | en_US |
dc.subject | Lattice Boltzmann method | en_US |
dc.subject | Primary cilium | en_US |
dc.subject | Pulsatile flow | en_US |
dc.title | Numerical study on the dynamics of primary cilium in pulsatile flows by the immersed boundary-lattice Boltzmann method | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 21 | - |
dc.identifier.epage | 35 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 1 | - |
dc.identifier.doi | 10.1007/s10237-019-01192-8 | - |
dcterms.abstract | An explicit immersed boundary-lattice Boltzmann method is applied to numerically investigate the dynamics of primary cilium in pulsatile blood flows with two-way fluid–structure interaction considered. To well characterize the effect of cilium basal body on cilium dynamics, the cilium base is modeled as a nonlinear rotational spring attached to the cilium’s basal end as proposed by Resnick (Biophys J 109:18–25, 2015. https://doi.org/10.1016/j.bpj.2015.05.031). After several careful validations, the fluid–cilium interaction system is investigated in detail at various pulsatile flow conditions that are characterized by peak Reynolds numbers (Repeak) and Womersley numbers (Wo). The periodic flapping of primary cilium observed in our simulations is very similar to the in vivo ciliary oscillation captured by O’Connor et al. (Cilia 2:8, 2013. https://doi.org/10.1186/2046-2530-2-8). The cilium’s dynamics is found to be closely related to the Repeak and Wo. Increase the Repeak or decrease the Wo bring to an increase in the cilium’s flapping amplitude, tip angular speed, basal rotation, and maximum tensile stress. It is also demonstrated that by reducing the Repeak or enhancing the Wo to a certain level, one can shift the flapping pattern of cilium from its original two-side one to a one-side one, making the stretch only happen on one particular side. During the flapping process, the location of the maximum tensile stress is not always found at the basal region; instead, it is able to propagate from time to time within a certain distance to the base. Due to the obstruction of the primary cilium, the distribution of wall shear stress no longer remains uniform as in the absence of cilia. It oscillates in space with the minimum magnitude which is always found near where the cilium is located. The presence of cilium also reduces the overall level of wall shear stress, especially at the region near the cilium’s anchor point. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Biomechanics and modeling in mechanobiology, Feb. 2020, v. 19, no. 1, p. 21-35 | - |
dcterms.isPartOf | Biomechanics and modeling in mechanobiology | - |
dcterms.issued | 2020-02 | - |
dc.identifier.scopus | 2-s2.0-85068225088 | - |
dc.identifier.pmid | 31256275 | - |
dc.identifier.eissn | 1617-7940 | - |
dc.description.validate | 202405 bcch | - |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | ME-0309 | en_US |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | PolyU | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 43211026 | en_US |
dc.description.oaCategory | Green (AAM) | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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Cui_Numerical_Study_Dynamics.pdf | Pre-Published version | 2.19 MB | Adobe PDF | View/Open |
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