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Title: Functional connexin35 increased in the myopic chicken retina
Authors: Banerjee, S 
Wang, Q 
Tang, G
So, C 
Shan, SW 
Li, KK 
Do, CW 
Pan, F 
Issue Date: 2021
Source: Visual Neuroscience, 2021. v. 38, E008
Abstract: Our previous research showed that increased phosphorylation of connexin (Cx)36 indicated extended coupling of AII amacrine cells (ACs) in the rod-dominant mouse myopic retina. This research will determine whether phosphorylation at serine 276 of Cx35-containing gap junctions increased in the myopic chicken, whose retina is cone-dominant. Refractive errors and ocular biometric dimensions of 7-days-old chickens were determined following 12 h and 7 days induction of myopia by a −10D lens. The expression pattern and size of Cx35-positive plaques were examined in the early (12 h) and compensated stages (7 days) of lens-induced myopia (LIM). At the same time, phosphorylation at serine 276 (functional assay) of Cx35 in strata 5 (S5) of the inner plexiform layer was investigated. The axial length of the 7 days LIM eyes was significantly longer than that of non-LIM controls (P < 0.05). Anti-phospho-Ser276 (Ser276-P)-labeled plaques were significantly increased in LIM retinas at both 12 h and 7 days. The density of Ser276-P of Cx35 was observed to increase after 12 h LIM. In the meanwhile, the areas of existing Cx35 plaques did not change. As there was more phosphorylation of connexin35 at Ser276 at both the early and late stages (12 h) and 7 days of LIM chicken retinal activity, the coupling with ACs could be increased in myopia development of the cone-dominated chicken retina.
Keywords: Myopia
Gap junction
Amacrine cell
Publisher: Cambridge University Press
Journal: Visual Neuroscience 
ISSN: 0952-5238
EISSN: 1469-8714
DOI: 10.1017/S0952523821000079
Rights: © School of Optometry, The Hong Kong Polytechnic University, 2021. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following publication Banerjee, S., Wang, Q., Tang, G., So, C., Shan, S. W., Li, K. K., ... & Pan, F. (2021). Functional connexin35 increased in the myopic chicken retina. Visual Neuroscience, 38:E008 is available at
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