Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81324
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Title: Endogenous H2S-Triggered in situ synthesis of NIR-II-Emitting nanoprobe for in vivo intelligently lighting up colorectal cancer
Authors: Deng, ZM
Jiang, MY
Li, YB
Liu, HR
Zeng, SJ
Hao, JH 
Issue Date: 2019
Source: iScience, 26 July 2019, v. 17, p. 217-224
Abstract: Overexpression of endogenous H2S is one of the key characteristic in colon cancer. However, developing endogenous H2S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H2S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000-1,400 nm via endogenous H2S-induced in situ chemical reaction to form Ag2S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise location of colorectal cancer via endogenous H2S activation. Therefore, our findings provide a new route for specifically targeting diagnosis of colon cancer based on the in situ-activatable NIR-II probe.
Publisher: Cell Press
Journal: iScience 
EISSN: 2589-0042
DOI: 10.1016/j.isci.2019.06.034
Rights: ©2019 The Author(s).
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
The following publication Deng, Z. M., Jiang, M. Y., Li, Y. B., Liu, H. R., Zeng, S. J., & Hao, J. H. (2019). Endogenous H2S-Triggered in situ synthesis of NIR-II-Emitting nanoprobe for in vivo intelligently lighting up colorectal cancer. iScience, 17, 217-224 is available at https://dx.doi.org/10.1016/j.isci.2019.06.034
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