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Title: Synthesis of strontium chondroitin sulfate and the evaluation of its capability to attenuate osteoarthritis
Authors: Ma, FB
Liu, N
Hu, N
Wen, CY 
Tang, B
Issue Date: 15-Aug-2017
Source: Carbohydrate polymers, 15 Aug. 2017, v. 170, p. 217-225
Abstract: Osteoarthritis (OA) is the most prevalent musculoskeletal disorder and the leading cause of joint disability in elderly patients. In this study, we fabricated strontium chondroitin sulfate (SrCS), a new polysaccharide-metal ion complex that is the combination of chondroitin sulfate and strontium, which are two widely adopted chemicals in OA clinical management. The structural, chemical compositions and morphology of as-fabricated SrCS were systematically investigated. Cell proliferation test, RT-PCR and preliminary animal studies were conducted to evaluate the clinical potential of SrCS on OA treatment. The materials characterization results verified that the Sr was successfully integrated into CS by replacing sodium in the original structure and formed a new polysaccharide-metal ion complex. The cell proliferation results indicated that the SrCS has excellent biocompatibility for both chondrocyte and osteoblast. The RT-PCR results showed that the SrCS can significantly increase the expression of COLII and ACAN, decrease MMP1 and MMP13 in chondrocyte and decrease the IL-6 and IL-1 beta in both chondrocyte and osteoblast. Preliminary animal studies demonstrated that SrCS can effectively simulate the articular cartilage formation in SD-rats after modified Hulth's OA modeling surgery. We therefore believed that the SrCS should be a rather effective chemical for OA clinical management as well as a beneficial component for various biomaterials in cartilage tissue engineering.
Keywords: Chondroitin sulfate
Strontium
Cartilage
Osteoarthritis
Publisher: Elsevier
Journal: Carbohydrate polymers 
ISSN: 0144-8617
EISSN: 1879-1344
DOI: 10.1016/j.carbpol.2017.04.067
Rights: © 2017 Elsevier Ltd. All rights reserved.
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
The following publication Ma, F. B., Liu, N., Hu, N., Wen, C. Y., & Tang, B. (2017). Synthesis of strontium chondroitin sulfate and the evaluation of its capability to attenuate osteoarthritis. Carbohydrate polymers, 170, 217-225 is available at https://doi.org/10.1016/j.carbpol.2017.04.067
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