Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/70484
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dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorMa, FBen_US
dc.creatorLiu, Nen_US
dc.creatorHu, Nen_US
dc.creatorWen, CYen_US
dc.creatorTang, Ben_US
dc.date.accessioned2017-12-28T06:17:01Z-
dc.date.available2017-12-28T06:17:01Z-
dc.identifier.issn0144-8617en_US
dc.identifier.urihttp://hdl.handle.net/10397/70484-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2017 Elsevier Ltd. All rights reserved.en_US
dc.rights© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.rightsThe following publication Ma, F. B., Liu, N., Hu, N., Wen, C. Y., & Tang, B. (2017). Synthesis of strontium chondroitin sulfate and the evaluation of its capability to attenuate osteoarthritis. Carbohydrate polymers, 170, 217-225 is available at https://doi.org/10.1016/j.carbpol.2017.04.067en_US
dc.subjectChondroitin sulfateen_US
dc.subjectStrontiumen_US
dc.subjectCartilageen_US
dc.subjectOsteoarthritisen_US
dc.titleSynthesis of strontium chondroitin sulfate and the evaluation of its capability to attenuate osteoarthritisen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage217en_US
dc.identifier.epage225en_US
dc.identifier.volume170en_US
dc.identifier.doi10.1016/j.carbpol.2017.04.067en_US
dcterms.abstractOsteoarthritis (OA) is the most prevalent musculoskeletal disorder and the leading cause of joint disability in elderly patients. In this study, we fabricated strontium chondroitin sulfate (SrCS), a new polysaccharide-metal ion complex that is the combination of chondroitin sulfate and strontium, which are two widely adopted chemicals in OA clinical management. The structural, chemical compositions and morphology of as-fabricated SrCS were systematically investigated. Cell proliferation test, RT-PCR and preliminary animal studies were conducted to evaluate the clinical potential of SrCS on OA treatment. The materials characterization results verified that the Sr was successfully integrated into CS by replacing sodium in the original structure and formed a new polysaccharide-metal ion complex. The cell proliferation results indicated that the SrCS has excellent biocompatibility for both chondrocyte and osteoblast. The RT-PCR results showed that the SrCS can significantly increase the expression of COLII and ACAN, decrease MMP1 and MMP13 in chondrocyte and decrease the IL-6 and IL-1 beta in both chondrocyte and osteoblast. Preliminary animal studies demonstrated that SrCS can effectively simulate the articular cartilage formation in SD-rats after modified Hulth's OA modeling surgery. We therefore believed that the SrCS should be a rather effective chemical for OA clinical management as well as a beneficial component for various biomaterials in cartilage tissue engineering.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationCarbohydrate polymers, 15 Aug. 2017, v. 170, p. 217-225en_US
dcterms.isPartOfCarbohydrate polymersen_US
dcterms.issued2017-08-15-
dc.identifier.isiWOS:000402942900025-
dc.identifier.pmid28521989-
dc.identifier.ros2016004443-
dc.identifier.eissn1879-1344en_US
dc.identifier.rosgroupid2016004359-
dc.description.ros2016-2017 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validatebcrcen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumberBME-0195-
dc.description.fundingSourceOthersen_US
dc.description.fundingTextNatural Science Foundation of China; Guangdong Natural Science Foundation; Shenzhen Science and Technology Innovation Committeeen_US
dc.description.pubStatusPublisheden_US
dc.identifier.OPUS70484-
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