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Title: | Simulation of deformation and aggregation of two red blood cells in a stenosed microvessel by dissipative particle dynamics | Authors: | Xiao, L Liu, Y Chen, S Fu, B |
Issue Date: | Dec-2016 | Source: | Cell biochemistry and biophysics, Dec. 2016, v. 74, no. 4, p. 513-525 | Abstract: | The motion of two red blood cells in a stenosed microvessel was simulated using dissipative particle dynamics. The effects of intercellular interaction, red blood cell deformability and the initial cell orientation on the deformation and aggregation of the RBCs and on the flow resistance were investigated. The red blood cell membrane was treated as a three-dimensional coarse-grained network model and the intercellular interaction was modeled by the Morse potential based on a depletion-mediated assumption. It is shown that the flow resistance increases dramatically when the red blood cells enter into the stenosis and decreases rapidly as RBCs move away from the stenosis. Particularly, for a pair of stiffer red blood cells with the initial inclination angle of 90°, the maximum value of the flow resistance is larger; while a higher flow resistance can also come from a stronger aggregation. For a pair of stiffer red blood cells moving parallel to the main flow, when their positions are closer to the vessel wall at the upstream of the stenosis, the flow resistance increases due to the migration to the vessel center at the stenosis. In addition, for a pair of red blood cells with the initial inclination angle of 0°, the flow resistance from the aggregate formed by a pair of red blood cells with a larger deformation is higher. | Keywords: | Deformation and aggregation Dissipative particle dynamics Flow resistance Intercellular interaction Red blood cells |
Publisher: | Humana Press | Journal: | Cell biochemistry and biophysics | ISSN: | 1085-9195 | EISSN: | 1559-0283 | DOI: | 10.1007/s12013-016-0765-2 | Rights: | © Springer Science+Business Media New York 2016 This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use(https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12013-016-0765-2. |
Appears in Collections: | Journal/Magazine Article |
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Liu_Simulation_Deformation_Aggregation.pdf | Pre-Published version | 1.6 MB | Adobe PDF | View/Open |
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