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Title: | Modification and enhanced anti-inflammatory activity by Bifidobacterial fermentation of an exopolysaccharide from a medicinal fungus Cs-HK1 | Authors: | Li, LQ Song, AX Wong, WT Wu, JY |
Issue Date: | 1-Oct-2021 | Source: | International journal of biological macromolecules, 1 Oct. 2021, v. 188, p. 586-594 | Abstract: | The exopolysaccharide (EPS) from the mycelial fermentation of a medicinal fungus Cordyceps sinensis Cs-HK1 had shown significant anti-inflammatory activity previously, and EPS-LM was a highly active fraction with a relatively low molecular weight (MW) isolated from the Cs-HK1 EPS. This study was to assess the effects of Bifidobacterial fermentation in anaerobic conditions on the molecular properties and anti-inflammatory activity of EPS-LM. In both Bifidobacterial cultures (B. breve and B. longum), EPS-LM was fractionally consumed as a carbon source, increasing the bacterial growth and acetic acid production. Analytical results from the fermentation digesta (supernatant) suggested that EPS-LM was partially degraded to lower molecular weight (MW) products with modified structures during the Bifidobacterial fermentation. More interestingly, the higher MW digesta fraction containing the partially degraded EPS-LM showed even stronger inhibiting activity than the original EPS-LM on the LPS-induced pro-inflammatory responses in THP-1 cell culture, including NF-κB activation, release of NO, TNF-α and IL-8. The study has shown that the fermentation by selected Bifidobacterial strains is effective to modify natural polysaccharides with enhanced bioactivities. | Keywords: | Anti-inflammatory activity Bifidobacterial fermentation Exopolysaccharide |
Publisher: | Elsevier | Journal: | International journal of biological macromolecules | EISSN: | 0141-8130 | DOI: | 10.1016/j.ijbiomac.2021.08.084 | Rights: | © 2021 Elsevier B.V. All rights reserved. © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The following publication Li, L. Q., Song, A. X., Wong, W. T., & Wu, J. Y. (2021). Modification and enhanced anti-inflammatory activity by Bifidobacterial fermentation of an exopolysaccharide from a medicinal fungus Cs-HK1. International Journal of Biological Macromolecules, 188, 586-594 is available at https://doi.org/10.1016/j.ijbiomac.2021.08.084. |
Appears in Collections: | Journal/Magazine Article |
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