Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/95471
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.contributor | Research Institute for Future Food | - |
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Li, LQ | en_US |
dc.creator | Song, AX | en_US |
dc.creator | Wong, WT | en_US |
dc.creator | Wu, JY | en_US |
dc.date.accessioned | 2022-09-19T02:22:10Z | - |
dc.date.available | 2022-09-19T02:22:10Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/95471 | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | © 2021 Elsevier B.V. All rights reserved. | en_US |
dc.rights | © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. | en_US |
dc.rights | The following publication Li, L. Q., Song, A. X., Wong, W. T., & Wu, J. Y. (2021). Modification and enhanced anti-inflammatory activity by Bifidobacterial fermentation of an exopolysaccharide from a medicinal fungus Cs-HK1. International Journal of Biological Macromolecules, 188, 586-594 is available at https://doi.org/10.1016/j.ijbiomac.2021.08.084. | en_US |
dc.subject | Anti-inflammatory activity | en_US |
dc.subject | Bifidobacterial fermentation | en_US |
dc.subject | Exopolysaccharide | en_US |
dc.title | Modification and enhanced anti-inflammatory activity by Bifidobacterial fermentation of an exopolysaccharide from a medicinal fungus Cs-HK1 | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 586 | en_US |
dc.identifier.epage | 594 | en_US |
dc.identifier.volume | 188 | en_US |
dc.identifier.doi | 10.1016/j.ijbiomac.2021.08.084 | en_US |
dcterms.abstract | The exopolysaccharide (EPS) from the mycelial fermentation of a medicinal fungus Cordyceps sinensis Cs-HK1 had shown significant anti-inflammatory activity previously, and EPS-LM was a highly active fraction with a relatively low molecular weight (MW) isolated from the Cs-HK1 EPS. This study was to assess the effects of Bifidobacterial fermentation in anaerobic conditions on the molecular properties and anti-inflammatory activity of EPS-LM. In both Bifidobacterial cultures (B. breve and B. longum), EPS-LM was fractionally consumed as a carbon source, increasing the bacterial growth and acetic acid production. Analytical results from the fermentation digesta (supernatant) suggested that EPS-LM was partially degraded to lower molecular weight (MW) products with modified structures during the Bifidobacterial fermentation. More interestingly, the higher MW digesta fraction containing the partially degraded EPS-LM showed even stronger inhibiting activity than the original EPS-LM on the LPS-induced pro-inflammatory responses in THP-1 cell culture, including NF-κB activation, release of NO, TNF-α and IL-8. The study has shown that the fermentation by selected Bifidobacterial strains is effective to modify natural polysaccharides with enhanced bioactivities. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | International journal of biological macromolecules, 1 Oct. 2021, v. 188, p. 586-594 | en_US |
dcterms.isPartOf | International journal of biological macromolecules | en_US |
dcterms.issued | 2021-10-01 | - |
dc.identifier.scopus | 2-s2.0-85112544097 | - |
dc.identifier.pmid | 34403670 | - |
dc.identifier.eissn | 0141-8130 | en_US |
dc.description.validate | 202209 bcww | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | ABCT-0036 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Hong Kong Polytechnic University | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 55718508 | - |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Li_Modification_Enhanced_Anti-Inflammatory.pdf | Pre-Published version | 987.75 kB | Adobe PDF | View/Open |
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