Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/94137
Title: | Copper-catalyzed synthesis of functionalized aryl sulfonamides from sodium sulfinates in green solvents | Authors: | Lam, LY Chan, KH Ma, C |
Issue Date: | 2022 | Source: | Journal of organic chemistry, 2022, v. 87, no. 13, p. 8802-8810 | Abstract: | Functionalized aryl sulfonamides are important building blocks in the pharmaceutical industry. A one-step synthesis catalyzed by a copper salt was developed using stable solid commodity chemicals in sulfolane or, alternatively, in green solvents such as γ-valerolactone, iPrOAc, or nBuOAc with acetic acid. The method tolerated diverse functional groups commonly presented in current medicines and drug intermediates. The mechanistic study showed a radical coupling pathway between the sulfonyl and anilinium radicals through the use of K2S2O8 and copper catalyst, respectively. | Publisher: | American Chemical Society | Journal: | Journal of organic chemistry | ISSN: | 0022-3263 | EISSN: | 1520-6904 | DOI: | 10.1021/acs.joc.2c00777 | Rights: | © 2022 American Chemical Society This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acs.joc.2c00777. |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Long_Copper-Catalyzed_Synthesis_Functionalized.pdf | Pre-Published version | 1.18 MB | Adobe PDF | View/Open |
Page views
62
Last Week
0
0
Last month
Citations as of May 5, 2024
Downloads
51
Citations as of May 5, 2024
SCOPUSTM
Citations
10
Citations as of Apr 26, 2024
WEB OF SCIENCETM
Citations
9
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.