Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/92390
Title: | Precise ultrasound neuromodulation in a deep brain region using nano gas vesicles as actuators | Authors: | Hou, X Qiu, Z Xian, Q Kala, S Jing, J Wong, KF Zhu, J Guo, J Zhu, T Yang, M Sun, L |
Issue Date: | Nov-2021 | Source: | Advanced science, 3 Nov. 2021, v. 8, no. 21, 2101934 | Abstract: | Ultrasound is a promising new modality for non-invasive neuromodulation. Applied transcranially, it can be focused down to the millimeter or centimeter range. The ability to improve the treatment's spatial resolution to a targeted brain region could help to improve its effectiveness, depending upon the application. The present paper details a neurostimulation scheme using gas-filled nanostructures, gas vesicles (GVs), as actuators for improving the efficacy and precision of ultrasound stimuli. Sonicated primary neurons display dose-dependent, repeatable Ca2+ responses, closely synced to stimuli, and increased nuclear expression of the activation marker c-Fos in the presence of GVs. GV-mediated ultrasound triggered rapid and reversible Ca2+ responses in vivo and could selectively evoke neuronal activation in a deep-seated brain region. Further investigation indicate that mechanosensitive ion channels are important mediators of this effect. GVs themselves and the treatment scheme are also found not to induce significant cytotoxicity, apoptosis, or membrane poration in treated cells. Altogether, this study demonstrates a simple and effective method to achieve enhanced and better-targeted neurostimulation with non-invasive low-intensity ultrasound. | Keywords: | Low-frequency ultrasound Nano gas vesicles Transcranial ultrasound stimulation Ultrasonic neuromodulation |
Publisher: | Wiley-VCH | Journal: | Advanced science | ISSN: | 2198-3844 | DOI: | 10.1002/advs.202101934 | Rights: | © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction inany medium, provided the original work is properly cited. The following publication Hou, X., Qiu, Z., Xian, Q., Kala, S., Jing, J., Wong, K. F., Zhu, J., Guo, J., Zhu, T., Yang, M., Sun, L., Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators. Adv. Sci. 2021, 8, 2101934 is available at https://doi.org/10.1002/advs.202101934 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Hou_Precise_Ultrasound_Neuromodulation.pdf | 3.02 MB | Adobe PDF | View/Open |
Page views
53
Last Week
1
1
Last month
Citations as of Apr 28, 2024
Downloads
38
Citations as of Apr 28, 2024
SCOPUSTM
Citations
23
Citations as of Apr 26, 2024
WEB OF SCIENCETM
Citations
20
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.