Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/92390
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Hou, X | en_US |
dc.creator | Qiu, Z | en_US |
dc.creator | Xian, Q | en_US |
dc.creator | Kala, S | en_US |
dc.creator | Jing, J | en_US |
dc.creator | Wong, KF | en_US |
dc.creator | Zhu, J | en_US |
dc.creator | Guo, J | en_US |
dc.creator | Zhu, T | en_US |
dc.creator | Yang, M | en_US |
dc.creator | Sun, L | en_US |
dc.date.accessioned | 2022-03-29T04:25:56Z | - |
dc.date.available | 2022-03-29T04:25:56Z | - |
dc.identifier.issn | 2198-3844 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/92390 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH | en_US |
dc.rights | © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction inany medium, provided the original work is properly cited. | en_US |
dc.rights | The following publication Hou, X., Qiu, Z., Xian, Q., Kala, S., Jing, J., Wong, K. F., Zhu, J., Guo, J., Zhu, T., Yang, M., Sun, L., Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators. Adv. Sci. 2021, 8, 2101934 is available at https://doi.org/10.1002/advs.202101934 | en_US |
dc.subject | Low-frequency ultrasound | en_US |
dc.subject | Nano gas vesicles | en_US |
dc.subject | Transcranial ultrasound stimulation | en_US |
dc.subject | Ultrasonic neuromodulation | en_US |
dc.title | Precise ultrasound neuromodulation in a deep brain region using nano gas vesicles as actuators | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 21 | en_US |
dc.identifier.doi | 10.1002/advs.202101934 | en_US |
dcterms.abstract | Ultrasound is a promising new modality for non-invasive neuromodulation. Applied transcranially, it can be focused down to the millimeter or centimeter range. The ability to improve the treatment's spatial resolution to a targeted brain region could help to improve its effectiveness, depending upon the application. The present paper details a neurostimulation scheme using gas-filled nanostructures, gas vesicles (GVs), as actuators for improving the efficacy and precision of ultrasound stimuli. Sonicated primary neurons display dose-dependent, repeatable Ca2+ responses, closely synced to stimuli, and increased nuclear expression of the activation marker c-Fos in the presence of GVs. GV-mediated ultrasound triggered rapid and reversible Ca2+ responses in vivo and could selectively evoke neuronal activation in a deep-seated brain region. Further investigation indicate that mechanosensitive ion channels are important mediators of this effect. GVs themselves and the treatment scheme are also found not to induce significant cytotoxicity, apoptosis, or membrane poration in treated cells. Altogether, this study demonstrates a simple and effective method to achieve enhanced and better-targeted neurostimulation with non-invasive low-intensity ultrasound. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Advanced science, 3 Nov. 2021, v. 8, no. 21, 2101934 | en_US |
dcterms.isPartOf | Advanced science | en_US |
dcterms.issued | 2021-11 | - |
dc.identifier.scopus | 2-s2.0-85115231802 | - |
dc.identifier.pmid | 34546652 | - |
dc.identifier.artn | 2101934 | en_US |
dc.description.validate | 202203 bcfc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a1631 | - |
dc.identifier.SubFormID | 45672 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Others: Innovation and Technology Fund | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Hou_Precise_Ultrasound_Neuromodulation.pdf | 3.02 MB | Adobe PDF | View/Open |
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