Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/92382
Title: | Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene-Related Peptide | Authors: | Mi, J Xu, JK Yao, Z Yao, H Li, Y He, X Dai, BY Zou, L Tong, WX Zhang, XT Hu, PJ Ruan, YC Tang, N Guo, X Zhao, J He, JF Qin, L |
Issue Date: | 5-Jan-2022 | Source: | Advanced science, 5 Jan. 2022, v. 9, no. 1, 2103005 | Abstract: | The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited. Here it is shown that electrical stimulation (ES) directly promotes the biosynthesis and release of calcitonin gene-related peptide (CGRP) by activating Ca2+/CaMKII/CREB signaling pathway and action potential, respectively. To accelerate rat femoral osteoporotic fracture healing which presents with decline of CGRP, soft electrodes are engineered and they are implanted at L3 and L4 dorsal root ganglions (DRGs). ES delivered at DRGs for the first two weeks after fracture increases CGRP expression in both DRGs and fracture callus. It is also identified that CGRP is indispensable for type-H vessel formation, a biological event coupling angiogenesis and osteogenesis, contributing to ES-enhanced osteoporotic fracture healing. This proof-of-concept study shows for the first time that ES at lumbar DRGs can effectively promote femoral fracture healing, offering an innovative strategy using bioelectronic device to enhance bone regeneration. | Keywords: | Bone regeneration CGRP Dorsal root ganglions Electrical stimulation |
Publisher: | Wiley-VCH | Journal: | Advanced science | ISSN: | 2198-3844 | DOI: | 10.1002/advs.202103005 | Rights: | © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Mi J., Xu J.-K., Yao Z., Yao H., Li Y., He X., Dai B.-Y., Zou L., Tong W.-X., Zhang X.-T., Hu P.-J., Ruan Y.C., Tang N., Guo X., Zhao J., He J.-F., Qin L. (2022). Implantable electrical stimulation at dorsal root ganglions accelerates osteoporotic fracture healing via calcitonin gene-related peptide. Advanced science, 5 Jan 2022, v. 9, no. 1, 2103005 is available at https://doi.org/10.1002/advs.202103005 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Mi_Implantable_Electrical_Stimulation.pdf | 5.88 MB | Adobe PDF | View/Open |
Page views
61
Last Week
0
0
Last month
Citations as of Apr 28, 2024
Downloads
69
Citations as of Apr 28, 2024
SCOPUSTM
Citations
47
Citations as of May 3, 2024
WEB OF SCIENCETM
Citations
44
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.