Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/92382
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Mi, J | en_US |
dc.creator | Xu, JK | en_US |
dc.creator | Yao, Z | en_US |
dc.creator | Yao, H | en_US |
dc.creator | Li, Y | en_US |
dc.creator | He, X | en_US |
dc.creator | Dai, BY | en_US |
dc.creator | Zou, L | en_US |
dc.creator | Tong, WX | en_US |
dc.creator | Zhang, XT | en_US |
dc.creator | Hu, PJ | en_US |
dc.creator | Ruan, YC | en_US |
dc.creator | Tang, N | en_US |
dc.creator | Guo, X | en_US |
dc.creator | Zhao, J | en_US |
dc.creator | He, JF | en_US |
dc.creator | Qin, L | en_US |
dc.date.accessioned | 2022-03-29T04:25:52Z | - |
dc.date.available | 2022-03-29T04:25:52Z | - |
dc.identifier.issn | 2198-3844 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/92382 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH | en_US |
dc.rights | © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | Mi J., Xu J.-K., Yao Z., Yao H., Li Y., He X., Dai B.-Y., Zou L., Tong W.-X., Zhang X.-T., Hu P.-J., Ruan Y.C., Tang N., Guo X., Zhao J., He J.-F., Qin L. (2022). Implantable electrical stimulation at dorsal root ganglions accelerates osteoporotic fracture healing via calcitonin gene-related peptide. Advanced science, 5 Jan 2022, v. 9, no. 1, 2103005 is available at https://doi.org/10.1002/advs.202103005 | en_US |
dc.subject | Bone regeneration | en_US |
dc.subject | CGRP | en_US |
dc.subject | Dorsal root ganglions | en_US |
dc.subject | Electrical stimulation | en_US |
dc.title | Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene-Related Peptide | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.doi | 10.1002/advs.202103005 | en_US |
dcterms.abstract | The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited. Here it is shown that electrical stimulation (ES) directly promotes the biosynthesis and release of calcitonin gene-related peptide (CGRP) by activating Ca2+/CaMKII/CREB signaling pathway and action potential, respectively. To accelerate rat femoral osteoporotic fracture healing which presents with decline of CGRP, soft electrodes are engineered and they are implanted at L3 and L4 dorsal root ganglions (DRGs). ES delivered at DRGs for the first two weeks after fracture increases CGRP expression in both DRGs and fracture callus. It is also identified that CGRP is indispensable for type-H vessel formation, a biological event coupling angiogenesis and osteogenesis, contributing to ES-enhanced osteoporotic fracture healing. This proof-of-concept study shows for the first time that ES at lumbar DRGs can effectively promote femoral fracture healing, offering an innovative strategy using bioelectronic device to enhance bone regeneration. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Advanced science, 5 Jan. 2022, v. 9, no. 1, 2103005 | en_US |
dcterms.isPartOf | Advanced science | en_US |
dcterms.issued | 2022-01-05 | - |
dc.identifier.scopus | 2-s2.0-85117909532 | - |
dc.identifier.pmid | 34708571 | - |
dc.identifier.artn | 2103005 | en_US |
dc.description.validate | 202203 bcch | en_US |
dc.description.oa | Version of Record | en_US |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Natural Science Foundation of China | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Mi_Implantable_Electrical_Stimulation.pdf | 5.88 MB | Adobe PDF | View/Open |
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